|
|
| | sPLA2 (Type IB) Rabbit Monoclonal Antibody (Clone 001) Basic information |
| | sPLA2 (Type IB) Rabbit Monoclonal Antibody (Clone 001) Chemical Properties |
| | sPLA2 (Type IB) Rabbit Monoclonal Antibody (Clone 001) Usage And Synthesis |
| Description | Secretory phospholipase A2 (sPLA2) (Type IB) is a calcium-dependent PLA2 superfamily member that is encoded by PLA2G1B in humans.1 It is composed of an N-terminal signal peptide, a highly-conserved calcium-binding loop, a catalytic domain, an sPLA2 Type I-specific disulfide bond that provides stability, and a pancreatic loop. It is primarily expressed in the pancreas but is also expressed in the lung.2 Upon activation, sPLA2 (Type IB) is released into the extracellular space and preferentially hydrolyzes phosphatidylglycerol (PG), phosphatidylcholine (PC), and phosphatidic acid (PA), over phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).3 It is involved in lipid nutrient digestion and absorption and also has anthelmintic activity.4 Pla2g1b-/- mice fed a high-fat diet are resistant to obesity and have decreased blood glucose and serum insulin levels and increased fecal lipid levels.5 Mutations in PLA2G1B are associated with central adiposity and colorectal cancer.4 Cayman’s sPLA2 (Type IB) Rabbit Monoclonal Antibody (Clone 001) can be used for ELISA.WARNING This product is not for human or veterinary use. |
| | sPLA2 (Type IB) Rabbit Monoclonal Antibody (Clone 001) Preparation Products And Raw materials |
|