TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE

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Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
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Products Intro: CAS:132414-81-4
Purity:97% Package:g-Kg Remarks:Light yellow liquid
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Products Intro: Product Name:5-Boc-hexahydropyrrolo[3,4-b]pyrrole
CAS:132414-81-4
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-01223
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Products Intro: Product Name:hexahydropyrrolo(3,4-b)pyrrole-5-carboxylic acid tert-butyl ester
CAS:132414-81-4
Purity:0.99 Package:1kg
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Products Intro: Product Name:TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE
CAS:132414-81-4
Purity:99% Package:1g;1USD
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Products Intro: Product Name:tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate
CAS:132414-81-4
Purity:99% Package:1kg; 25kg; or larger package as required Remarks:pharmaceutical intermediates；Chemical Intermediate

TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE manufacturers
TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE Basic information
Product Name:TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE
Synonyms:Hexahydropyrrolo[3,4-b]pyrrole-5-carboxylic acid tert-butyl ester;5-N-Boc-hexahydro-pyrrolo[3,4-b]pyrrole;Tert-butyl 2,7-diazabicyclo[3.3.0]octan-7-carboxylate;Pyrrolo[3,4-b]pyrrole-5(1H)-carboxylic acid, hexahydro-, 1,1-diMethylethyl ester;Octahydro-pyrrolo[3,4-b]pyridine-6-carboxylic acid tert-butyl ester;t-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate;tert-butyl octahydropyrrolo[3,4-b]pyrrole-5-carboxylate;(3aR*,6aR*)-hexahydro-pyrrolo[3,4-b]pyrrole-5-carboxylic acid tert-butyl ester
CAS:132414-81-4
MF:C11H20N2O2
MW:212.29
EINECS:
Product Categories:
Mol File:132414-81-4.mol
TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE Structure
TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE Chemical Properties
Boiling point 295.4±13.0 °C(Predicted)
density 1.076±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form solid
pka10.72±0.20(Predicted)
AppearanceColorless to light yellow Liquid
Safety Information
Hazard Codes N
Risk Statements 50/53-50
Safety Statements 60-61
RIDADR UN3077
MSDS Information
TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE Usage And Synthesis
Synthesis
TERT-BUTYL 1-BENZYLHEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE

132414-80-3

TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE

132414-81-4

GENERAL STEPS: 1-benzyl-5-BOC-hexahydropyrrolo[3,4-B]pyrrole (1.68 g, 5.5 mmol) was dissolved in methanol (40 mL) under a nitrogen atmosphere, ammonium formate (3.5 g, 55.5 mmol) and palladium/carbon catalyst (600 mg) were added. The reaction mixture was heated to reflux for 2 h, subsequently cooled to room temperature and filtered through filter paper padded with methanol. The filtrate was concentrated under reduced pressure and the resulting residue was dissolved in dichloromethane and washed with sodium bicarbonate solution. The organic phase was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 5-Boc-hexahydropyrrolo[3,4-B]pyrrole (1.1 g, 93% yield) as a gray oil. Mass spectrum (m/z): 213.2 [M+H]+.

References[1] Patent: WO2017/21920, 2017, A1. Location in patent: Paragraph 0637; 0638
TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE Preparation Products And Raw materials
Raw materialsTERT-BUTYL 1-BENZYLHEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE-->Methanol-->Ammonium formate-->Palladium-->Activated carbon
Tag:TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE(132414-81-4) Related Product Information
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