| Company Name: |
Cool Pharm, Ltd |
| Tel: |
021-60455363 18019463053 |
| Email: |
sales@coolpharm.com |
| Company Name: |
DebyeTec.com Inc. |
| Tel: |
18086626237 18086626237 |
| Email: |
2693528373@qq.com |
4-bromo-2-(bromomethyl)-1-nitrobenzene manufacturers
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| | 4-bromo-2-(bromomethyl)-1-nitrobenzene Basic information |
| | 4-bromo-2-(bromomethyl)-1-nitrobenzene Chemical Properties |
| Boiling point | 330.2±27.0 °C(Predicted) | | density | 2.006±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | crystalline solid | | color | Light yellow |
| | 4-bromo-2-(bromomethyl)-1-nitrobenzene Usage And Synthesis |
| Synthesis | To a stirred solution of (5-bromo-2-nitrophenyl)methanol (2.8 g, 12.06 mmol) in a solvent mixture of dichloromethane (DCM) and acetonitrile (MeCN) (1:1, 100 mL) was added sequentially at 0 °C carbon tetrabromide (CBr4) (5.2 g, 15.68 mmol) and triphenylphosphine (PPh3) (4.1 g. 15.68 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by fast column chromatography on silica gel (petroleum ether (PE)/ethyl acetate (EA) = 50:1 to 10:1 gradient elution) to afford the target product 4-bromo-2-(bromomethyl)-1-nitrobenzene (1.1 g, 31% yield). | | References | [1] Patent: WO2018/68017, 2018, A1. Location in patent: Page/Page column 154; 155; 156; 157 |
| | 4-bromo-2-(bromomethyl)-1-nitrobenzene Preparation Products And Raw materials |
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