Ferroptosis Inhibitor D1

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Ferroptosis Inhibitor D1 Suppliers list
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Ferroptosis Inhibitor D1 Basic information
Product Name:Ferroptosis Inhibitor D1
Synonyms:Ferroptosis Inhibitor D1
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MW:0
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Ferroptosis Inhibitor D1 Structure
Ferroptosis Inhibitor D1 Chemical Properties
solubility DMSO: Soluble: =10 mg/ml
Safety Information
MSDS Information
Ferroptosis Inhibitor D1 Usage And Synthesis
DescriptionFerroptosis inhibitor D1 is a free radical scavenger and an inhibitor of ferroptosis.1 It scavenges 41.27% of DPPH (Item No. 14805) radicals in a cell-free assay when used at a concentration of 0.4 µM. Ferroptosis inhibitor D1 (0.5 µM) inhibits lipid peroxidation induced by the ferroptosis inducer erastin (Item No. 17754) in HT-1080 cells and inhibits erastin-induced ferroptosis in the same cells (IC50 = 22 nM). In vivo, ferroptosis inhibitor D1 (5 mg/kg) reduces infarct volume and improves neurological deficits in a mouse model of ischemic brain injury induced by transient middle cerebral artery occlusion (MCAO).WARNING This product is not for human or veterinary use.
References[1] YANG LU, JINXIN CHE*   Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers[J]. Journal of Medicinal Chemistry, 2024, 67 14: 11712-11731 11712-11731. DOI: 10.1021/acs.jmedchem.4c0021110.1021/acs.jmedchem.4c00211
Ferroptosis Inhibitor D1 Preparation Products And Raw materials
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