|
|
| | Transferrin Receptor Protein 1/CD71 Rabbit Monoclonal Antibody (Clone RM384) Basic information |
| | Transferrin Receptor Protein 1/CD71 Rabbit Monoclonal Antibody (Clone RM384) Chemical Properties |
| | Transferrin Receptor Protein 1/CD71 Rabbit Monoclonal Antibody (Clone RM384) Usage And Synthesis |
| Description | Transferrin receptor protein 1 (TfR1), also known as CD71, is a homodimeric transmembrane receptor for transferrin (Item No. 32030) that facilitates iron delivery into cells and is encoded by TFRC in human.1 It is composed of two TfR1 monomers, each composed of a 67-amino acid cytoplasmic tail with an internalization motif, a membrane spanning portion, a stalk region that covalently links the monomers, and an extracellular ectodomain. The ectodomain binds transferrin and is composed of an apical domain, a protease-like domain, and a helical domain that drives TfR1 dimerization.1,2 TfR1 is ubiquitously expressed, except on mature red blood cells and certain terminally differentiated cells, with the highest expression on immature erythroid cells and in the placenta, and is involved in erythropoiesis, lymphocyte development, and hematopoietic expansion in the bone marrow.3,4 TfR1/transferrin-mediated iron transport contributes to the intracellular iron pool required for ferroptosis and anti-TfR1 antibodies have been used in combination with anti-malondialdehyde antibodies to identify ferroptotic cells in vitro and human cancer tissue in a mouse xenograft model.5 A soluble form of TfR1 is present in serum and increased levels are associated with autoimmune hemolytic anemia, polycythemia vera, and iron deficiency anemia, while decreased levels are associated with chronic renal failure and aplastic anemia.6 TFRC is overexpressed in various breast cancer tumors and gliomas and positively correlated with poor prognosis.7 Cayman’s TfR1/CD71 Rabbit Monoclonal Antibody (Clone RM384) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | Transferrin Receptor Protein 1/CD71 Rabbit Monoclonal Antibody (Clone RM384) Preparation Products And Raw materials |
|