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| | STAT3α/β (Phospho-Tyr705) Rabbit Monoclonal Antibody (Clone RM261) Basic information |
| | STAT3α/β (Phospho-Tyr705) Rabbit Monoclonal Antibody (Clone RM261) Chemical Properties |
| | STAT3α/β (Phospho-Tyr705) Rabbit Monoclonal Antibody (Clone RM261) Usage And Synthesis |
| Description | STAT3 is a ubiquitously expressed transcription factor and member of the STAT protein family that has roles in a variety of cellular functions including proliferation, apoptosis, and differentiation, as well as innate and adaptive immunity and stem cell pluripotency.1,2,3 It contains N-terminal, coiled-coil, DNA binding, and linker domains that mediate nuclear translocation and export, as well as Src homology 2 (SH2) and C-terminal transactivation domains that are subject to phosphorylation.4,5 Alternative splicing of STAT3 pre-mRNA leads to the formation of the full-length isoform STAT3α, as well as STAT3β, a truncated isoform that lacks a portion of the transactivation domain and is considered a dominant-negative regulator of STAT3 transcriptional activation.6 STAT3 signaling is inhibited by the negative regulator suppressor of cytokine signaling 3 (SOCS-3) and prevents excessive STAT3 activation.2 Phosphorylation of STAT3 at tyrosine 705 (Tyr705) is mediated by JAKs in response to stimulation with cytokines or growth factors and induces STAT3 dimerization and nuclear translocation, leading to STAT3-dependent gene transcription.2,1 Tumor STAT3 (phospho-Tyr705) levels are increased in patients with squamous or renal cell carcinoma and are associated with metastasis.7,8 Cayman's STAT3α/β (Phospho-Tyr705) Rabbit Monoclonal Antibody (Clone RM261) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | STAT3α/β (Phospho-Tyr705) Rabbit Monoclonal Antibody (Clone RM261) Preparation Products And Raw materials |
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