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| | Cytokeratin 17 (C-Term) Rabbit Monoclonal Antibody (Clone RM351) Basic information |
| | Cytokeratin 17 (C-Term) Rabbit Monoclonal Antibody (Clone RM351) Chemical Properties |
| | Cytokeratin 17 (C-Term) Rabbit Monoclonal Antibody (Clone RM351) Usage And Synthesis |
| Description | Cytokeratin 17 (CK-17) is an intermediate filament protein and a member of the cytokeratin protein family encoded by KRT17 in humans.1 It is a type I acidic cytokeratin expressed in the basal cells of epithelial appendages, such as hair follicles and sebaceous glands, and is localized to the cytoplasm. CK-17 expression can be induced in the epidermis under conditions of cellular stress, such as viral infection, injury, or psoriasis. CK-17 is also expressed in squamous, basal, and urothelial carcinomas, as well as adenocarcinomas, and is associated with poor prognosis in breast, cervical, oral squamous, and gastric carcinomas.1,2 Heterozygous dominant mutations in KRT17 are associated with early onset alopecia.1 Missense mutations in KRT17 are associated with ectodermal dysplasias, including pachyonychia congenita and steatocystoma multiplex. Cayman’s Cytokeratin 17 (C-Term) Rabbit Monoclonal Antibody (Clone RM351) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | Cytokeratin 17 (C-Term) Rabbit Monoclonal Antibody (Clone RM351) Preparation Products And Raw materials |
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