- Notoginsenoside R1
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- $0.00 / 1KG
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2026-03-08
- CAS:80418-24-2
- Min. Order: 1KG
- Purity: 80% HPLC
- Supply Ability: 1000KG
- Notoginsenoside R1
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- $10.00 / 1KG
-
2026-03-06
- CAS:80418-24-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5tons
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| | Notoginsenoside R1 Chemical Properties |
| Melting point | 215～217℃ | | Boiling point | 1010.5±65.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | H2O: soluble1mg/mL, clear, colorless | | pka | 12.85±0.70(Predicted) | | form | powder | | color | white to off-white | | biological source | Panax notoginseng (Burk.) F.H.Chen | | Water Solubility | H2O: 1mg/mL, clear, colorless | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products | | InChIKey | LLPWNQMSUYAGQI-OOSPGMBYSA-N | | LogP | 1.354 (est) |
| | Notoginsenoside R1 Usage And Synthesis |
| Description | Notoginsenoside R1 is a ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane. | | Uses | Notoginsenoside R1 is an active ingredient isolated from Panax notoginseng that induces tissue-type plasminogen activator synthesis in cultured human umbilical vein endothelial cells. | | Application | Notoginsenoside R1 has a role as a plant metabolite, an antioxidant, a neuroprotective agent, an apoptosis inducer and a phytoestrogen. | | Chemical Properties | Derived from the dried root of Panax ginseng of the Araliaceae family | | Uses | Notoginsenoside R1 acts as an anti-inflammatory agent, inhibiting TNF-α induced PAI-1 production in aortic smooth muscle cells in humans. | | Definition | ChEBI: Notoginsenoside R1 is a ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an antioxidant, a neuroprotective agent, an apoptosis inducer and a phytoestrogen. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane. | | Biological Activity | Notoginsenoside R1 has been shown to exhibit antooxidant, anti-inflammatory, antiapoptotic, and immune-stimulatory properties. | | in vivo | Notoginsenoside R1 (5 mg/kg/h; infused via the right jugular vein) increases red blood cell velocity, reduces the number of adherent leukocytes and inhibits mast cell degranulation and cytokine elevation in rats[3]. | Animal Model: | Male Sprague-Dawley (SD) rats (200-250 g)[3] | | Dosage: | 5 mg/kg/h | | Administration: | Infused 20 min before LPS infusion via the right jugular vein | | Result: | Ameliorated the LPS-induced reduction in the mesenteric venular shear rate to some extent.
Attenuated the LPS-induced adhesion of leukocytes to the venular wall.
Inhibited mast cell degranulation and cytokine elevation. |
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| | Notoginsenoside R1 Preparation Products And Raw materials |
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