| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:DSPE-PEG(2000)-Mannose
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| Company Name: |
|
| Tel: |
19011298796 19011298796 |
| Email: |
17816380947@139.com |
| Products Intro: |
Product Name:DSPE-PEG(2000)-Mannose
Purity:98% HPLC Package:1MG/;100MG/
|
| Company Name: |
Shanghai Fengyong Biotechnology Co., Ltd.
|
| Tel: |
021-10000000 13000000000 |
| Email: |
gzj@abmole.cn |
| Products Intro: |
Product Name:DSPE-PEG2000-Mannose
Purity:>98.0% Package:5mg;10mg;50mg;100mg;1g;5g;10g;100g
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| | DSPE-PEG(2000)-Mannose Basic information |
| | DSPE-PEG(2000)-Mannose Chemical Properties |
| solubility | DMF: Slightly soluble: 0.1-1 mg/ml
DMSO: Slightly soluble: 0.1-1 mg/ml
Ethanol: Soluble: 10 mg/ml |
| | DSPE-PEG(2000)-Mannose Usage And Synthesis |
| Description | DSPE-PEG(2000)-mannose is a PEGylated and mannosylated form of 1,2-distearoyl-sn-glycero-3-PE (1,2-DSPE; Item No. 15095) that has been used in the generation of liposomes and lipid nanoparticles (LNPs) for the delivery of peptides, oligodeoxynucleotides, and siRNA in vitro and in vivo.1,2 Fluorescently labeled LNPs containing DSPE-PEG(2000)-mannose selectively accumulate in the liver and spleen over the brain, lungs, heart, kidney, and pancreas in mice.1 Immunization with liposomes containing DSPE-PEG(2000)-mannose and encapsulating human papilloma virus type 16 (HPV16) E7 peptide and CpG oligodeoxynucleotide as an adjuvant decrease tumor size, intratumoral CD4+ or CD8+ T cells, and intratumoral angiogenesis in a murine lung cancer model using TC-1 cells, which express HPV16 E6 and E7 peptides.2WARNING This product is not for human or veterinary use. | | References | [1] SANGHO YEO . Optimization of polyethylene glycol shielding and mannose density on the lipid nanoparticles for efficient delivery to macrophages and spleens[J]. International Journal of Pharmaceutics, 2024, 662: Article 124540. DOI: 10.1016/j.ijpharm.2024.124540
[2] YAN ZHAO. Mannose-Modified Liposome Co-Delivery of Human Papillomavirus Type 16 E7 Peptide and CpG Oligodeoxynucleotide Adjuvant Enhances Antitumor Activity Against Established Large TC-1 Grafted Tumors in Mice.[J]. International Journal of Nanomedicine, 2020: 9571-9586. DOI: 10.2147/ijn.s275670 |
| | DSPE-PEG(2000)-Mannose Preparation Products And Raw materials |
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