ICI 216140 (trifluoroacetate salt)

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ICI 216140 (trifluoroacetate salt) Suppliers list
Company Name: Cayman Chemical Company  
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ICI 216140 (trifluoroacetate salt) Basic information
Product Name:ICI 216140 (trifluoroacetate salt)
Synonyms:ICI 216140 (trifluoroacetate salt)
CAS:
MF:
MW:0
EINECS:
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Mol File:Mol File
ICI 216140 (trifluoroacetate salt) Structure
ICI 216140 (trifluoroacetate salt) Chemical Properties
solubility DMF: 2 mg/ml
DMSO: 2 mg/mlPBS (pH 7.2): 10 mg/ml
Safety Information
MSDS Information
ICI 216140 (trifluoroacetate salt) Usage And Synthesis
DescriptionICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50 = 2 nM in vitro).1 At 2 mg/kg, it can reduce bombesin-stimulated pancreatic amylase secretion in rats.1 At 1 mM, it has been shown to attenuate bombesin-stimulated increases in blood pressure in rats.2WARNING This product is not for human or veterinary use.
References[1] ROGER CAMBLE. NisobutyrylHisTrpAlaValDAlaHisLeuNHMe (ICI 226140) a potent in vivo antagonist analogue of bombesin/gastrin releasing peptide (BN/GRP) derived from the c-terminal sequence lacking the final methionine residue[J]. Life sciences, 1989, 45 17: Pages 1521-1527. DOI: 10.1016/0024-3205(89)90417-7
[2] BRANIMIR ZOGOVIC  Paul M P. Intrathecal bombesin is sympathoexcitatory and pressor in rat.[J]. American journal of physiology. Regulatory, integrative and comparative physiology, 2011: R1486-94. DOI: 10.1152/ajpregu.00297.2011
ICI 216140 (trifluoroacetate salt) Preparation Products And Raw materials
Tag:ICI 216140 (trifluoroacetate salt) Related Product Information
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