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| | Methyl 1-methylpiperidine-3-carboxylate Basic information |
| Product Name: | Methyl 1-methylpiperidine-3-carboxylate | | Synonyms: | 1-methyl-3-piperidinecarboxylicacimethylester;1-methylnipecoticacidmethylester;1-methyl-nipecoticacimethylester;dihydroarecoline;methyln-methylnipecotate;Methyl 1-methylpiperidine-3-carboxylate CAS no. 1690-72-8;n-methyl-3-carbomethoxypiperidine;1-Methyl-3-Piperidinelarboxylate | | CAS: | 1690-72-8 | | MF: | C8H15NO2 | | MW: | 157.21 | | EINECS: | 210-314-1 | | Product Categories: | Heterocyclic Compounds | | Mol File: | 1690-72-8.mol |  |
| | Methyl 1-methylpiperidine-3-carboxylate Chemical Properties |
| Boiling point | bp12 83-84° | | density | 1.013±0.06 g/cm3(Predicted) | | refractive index | nD25 1.4520 | | storage temp. | 2-8°C | | pka | pKa (20°): 8.66 | | Appearance | Colorless to light yellow Liquid | | CAS DataBase Reference | 1690-72-8(CAS DataBase Reference) |
| | Methyl 1-methylpiperidine-3-carboxylate Usage And Synthesis |
| Uses | Methyl 1-methylpiperidine-3-carboxylate belongs to the class of organic compounds known as piperidinecarboxylic acids. Piperidinecarboxylic acids are compounds containing a piperidine ring with a carboxylic acid group. Methyl 1-methylpiperidine-3-carboxylate is a strong basic compound (based on its pKa). It could be used to synthesize (1-methylpiperidin-3-yl)methanol. The specific steps are shown as follows: into a 500 mL round bottom flask containing a solution of methyl 1-methylpiperidine-3- carboxylate (12.0 g, 76 mmol) in tetrahydrofuran (500 mL) was added lithium aluminumhydride (4.3 g, 114 mmol) in portions at 0 °C. The reaction mixture was stirred at room temperature for 1 h. The reaction was quenched with methanol at 0 °C, and the precipitated solid was filtered through celite. The filtrate was concentrated and the crude was purified by flash chromatography eluting with methanol in dichloromethane (5-10percent) to afford (1-methylpiperidin-3-yl)methanol as a solid.
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| | Methyl 1-methylpiperidine-3-carboxylate Preparation Products And Raw materials |
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