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| | 3-Bromo-2-methoxypyridine Basic information |
| | 3-Bromo-2-methoxypyridine Chemical Properties |
| Boiling point | 87 °C(Press: 16 Torr) | | density | 1.5856 g/mL at 25 °C | | refractive index | 1.566 | | Fp | 93 °C | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | pka | 1.04±0.10(Predicted) | | form | clear liquid | | color | Colorless to Light yellow | | Water Solubility | Not miscible or difficult to mix in water. | | Sensitive | Moisture Sensitive/Light Sensitive | | InChI | 1S/C6H6BrNO/c1-9-6-5(7)3-2-4-8-6/h2-4H,1H3 | | InChIKey | PORGLLGXCAQORO-UHFFFAOYSA-N | | SMILES | COc1ncccc1Br | | CAS DataBase Reference | 13472-59-8(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-36/37/39 | | WGK Germany | 3 | | HS Code | 29333990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 3-Bromo-2-methoxypyridine Usage And Synthesis |
| Uses | It is employed in the facile synthesis of 2-unsubstituted benzofuran-3-carboxylates using diazo(trimethylsilyl)methyl magnesium bromide. | | Synthesis | A) 3-bromo-2-chloropyridine (4.76 g) was dissolved in N,N-dimethylformamide (DMF, 30 mL) under argon protection. Subsequently, a methanolic solution of 28% sodium methanol (5.73 g) was added to this solution. The reaction mixture was stirred at 80°C for 30 minutes. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the addition of water. The reaction mixture was extracted with ethyl acetate and the organic phases were combined. The organic phase was washed sequentially with water and saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product 3-bromo-2-methoxypyridine (4.43 g) as a light yellow oil. | | References | [1] Patent: EP2816023, 2014, A1. Location in patent: Paragraph 0393; 0394 |
| | 3-Bromo-2-methoxypyridine Preparation Products And Raw materials |
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