2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]

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2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:MuRF1-IN-1
CAS:445222-91-3
Purity:98.88% Package:1mg;46USD|5mg;98USD|10mg;158USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:MuRF1-IN-1
CAS:445222-91-3
Purity:98.88% Package:1mg;46USD|5mg;98USD|10mg;158USD
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:EMBL
CAS:445222-91-3
Purity:98% Package:1mg;5mg;10mg
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Products Intro: Product Name:EMBL
CAS:445222-91-3
Purity:>98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:2g
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 177-54423994 17754423994
Email: 2853530910@QQ.com
Products Intro: Product Name:MuRF1-IN-1
CAS:445222-91-3
Purity:98% HPLC LCMS Package:100mg;500mg;1g

2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] manufacturers

  • MuRF1-IN-1
  • MuRF1-IN-1 pictures
  • $32.00 / 1mg
  • 2026-03-13
  • CAS:445222-91-3
  • Min. Order:
  • Purity: 98.88%
  • Supply Ability: 10g
  • MuRF1-IN-1
  • MuRF1-IN-1 pictures
  • $32.00 / 1mg
  • 2026-03-13
  • CAS:445222-91-3
  • Min. Order:
  • Purity: 98.88%
  • Supply Ability: 10g
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Basic information
Product Name:2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]
Synonyms:2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene];MuRF1-IN-1;EMBL;2-Amino-1'-methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile;MuRF1IN1,inhibit,Inhibitor,MuRF1 IN 1,MuRF-1-IN-1;Spiro[4H-1-benzopyran-4,3'-[3H]indole]-3-carbonitrile, 2-amino-1',2',5,6,7,8-hexahydro-1'-methyl-2',5-dioxo-;MuRF1-IN-1, 10 mM in DMSO
CAS:445222-91-3
MF:C18H15N3O3
MW:321.33
EINECS:
Product Categories:
Mol File:445222-91-3.mol
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Structure
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Chemical Properties
Melting point 247-248 °C(Solv: ethanol (64-17-5))
Boiling point 716.6±60.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (389.01 mM; Need ultrasonic)
pka2.42±0.20(Predicted)
form Solid
color Off-white to gray
Safety Information
MSDS Information
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Usage And Synthesis
UsesMuRF1-IN-1 is a muscle ring finger 1 (MuRF1) inhibitor that attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia[1].
Biological ActivityMuRF1-IN-1 is a muscle ring finger 1 (MuRF1) inhibitor that attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia[1].
References[1]. Bowen TS, Adams V, Werner S, et al. Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953.
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Preparation Products And Raw materials
Tag:2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene](445222-91-3) Related Product Information