- trans-Clomiphene Citrate
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- $10.00 / 1ASSAYS
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2026-05-24
- CAS:7599-79-3
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 1 ton
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| | trans-Clomiphene Citrate Basic information |
| | trans-Clomiphene Citrate Chemical Properties |
| Melting point | 143-145°C | | storage temp. | Amber Vial, -20°C Freezer | | solubility | DMSO (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated) | | form | Solid | | color | White to Off-White | | Stability: | Light Sensitive | | InChIKey | PYTMYKVIJXPNBD-BTKVJIOYSA-N |
| | trans-Clomiphene Citrate Usage And Synthesis |
| Chemical Properties | Enclomiphene citrate is chemically an organic citrate with good photoluminescent properties in organic solutions due to the presence of a tristyrene unit in its structure. Due to the presence of a tertiary amine unit in the structure, it is sensitive to oxidants and is easily oxidized by oxidants to the corresponding nitrogen oxides. | | Uses | trans-Clomiphene Citrate, stereoisomer of Clomiphene Citrate (C587025), a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. | | Toxicology | The effects of the cis and trans isomers of clomiphene citrate on the uterine hexokinase activity of immature ovariectomized rats were studied in long- and short-term experiments. At a dose level of 600 μg/kg, both trans-Clomiphene Citrate and cis-Clomiphene Citrate caused a similar increase in total uterine hexokinase activity observable in 18 hr. When enzyme activity was expressed per g of the uterus (specific activity), significant increases were noted 18 hr after a single injection of trans clomiphene or after 4 daily injections of either isomer. Treatment of these animals with 170-estradiol (5 μg/kg) caused an elevation of both the specific and total hexokinase activities within 18 hr[1].
| | in vivo | Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6]. | Animal Model: | 21 days-old Charles River male rats[5] | | Dosage: | 0.25 and 0.5 mg/animal, daily for 24 days. | | Administration: | Subcutaneous injection | | Result: | Decreased LH and testosterone levels in the serum. |
| Animal Model: | OVX (ovariectomy) rat model[6] | | Dosage: | 0.03, 1, and 3 mg/kg, daily for 90 days. | | Administration: | Oral adminstration | | Result: | Reducted body weight to sham levels, and reduced serum cholesterol.
Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
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| | References | [1] D L DiPietro, D A Goss, F J Sanders. “Effect of cis and trans isomers of clomiphene citrate on uterine hexokinase activity.” Endocrinology 84 6 (1969): 1404–8. |
| | trans-Clomiphene Citrate Preparation Products And Raw materials |
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