- NU1025
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- $65.00 / 5mg
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2026-03-13
- CAS:90417-38-2
- Min. Order:
- Purity: 99.86%
- Supply Ability: 10g
- NU1025
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- $1.00 / 1KG
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2019-07-06
- CAS:90417-38-2
- Min. Order: 1KG
- Purity: 98-100%
- Supply Ability: 1000kg
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| Product Name: | NU1025 | | Synonyms: | NU1025;PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem;NU 1025;NU 1025;8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE;8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE;8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE;8-Hydroxy-2-methylquinazoline-4-one ,97%;8-hydroxy-2-methyl-1H-quinazolin-4-one | | CAS: | 90417-38-2 | | MF: | C9H8N2O2 | | MW: | 176.17 | | EINECS: | | | Product Categories: | All Inhibitors;Inhibitors;Aromatics | | Mol File: | 90417-38-2.mol |  |
| | NU1025 Chemical Properties |
| Melting point | 253-258°C | | Boiling point | 345.4±44.0 °C(Predicted) | | density | 1.42 | | storage temp. | −20°C | | solubility | DMSO: 35 mg/mL, soluble | | form | solid | | pka | 8.68±0.20(Predicted) | | color | off-white | | InChI | 1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13) | | InChIKey | YJDAOHJWLUNFLX-UHFFFAOYSA-N | | SMILES | CC1=Nc2c(O)cccc2C(=O)N1 | | CAS DataBase Reference | 90417-38-2 |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 29335990 | | Storage Class | 11 - Combustible Solids |
| | NU1025 Usage And Synthesis |
| Description | NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes. | | Chemical Properties | Off-White to Pale Yellow Solid | | Uses | NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical] | | Uses | A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively. | | Definition | ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase. | | Biological Activity | Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively. | | References | [1] ROGER J. GRIFFIN. Resistance-Modifying Agents. 5. 1 Synthesis and Biological Properties of Quinazolinone Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase (PARP)[J]. Journal of Medicinal Chemistry, 1998, 41 26: 5247-5256. DOI: 10.1021/jm980273t
[2] KJ BOWMAN. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064[J]. British Journal of Cancer, 1998, 78 10: 1269-1277. DOI: 10.1038/bjc.1998.670
[3] C A DELANEY. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.[J]. Clinical Cancer Research, 2000, 6 7: 2860-2867.
[4] SLAWOMIR KUMALA. Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors.[J]. PLoS ONE, 2013: e52966. DOI: 10.1371/journal.pone.0052966 |
| | NU1025 Preparation Products And Raw materials |
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