[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid

[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid Basic information

Product Name:	[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid
Synonyms:	[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid;L-657926;2-[(1S)-9-[(4-chlorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid;1H-Carbazole-1-acetic acid, 9-[(4-chlorophenyl)methyl]-6-fluoro-2,3,4,9-tetrahydro-, (1S)-
CAS:	113243-00-8
MF:	C21H19ClFNO2
MW:	371.83
EINECS:
Product Categories:
Mol File:	113243-00-8.mol

[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid Chemical Properties

Safety Information

MSDS Information

[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid Usage And Synthesis

Uses	L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-l-yl acetic acid. The IC50s of (-) and (+) configurations for TxA2 are 0.27 nM and 124 nM, respectively.
References	[1] Folger WH, Halushka PV, Wilcox CS, Guzman NJ. Characterization of rat glomerular thromboxane A2 receptors: comparison to rat platelets. Eur J Pharmacol. 1992 Sep 1;227(1):71-8. DOI:10.1016/0922-4106(92)90144-k

[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid Preparation Products And Raw materials

Tag:[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid(113243-00-8) Related Product Information

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