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| | α,α-Bis(hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3α-yl ester Basic information |
| Product Name: | α,α-Bis(hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3α-yl ester | | Synonyms: | α,α-Bis(hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3α-yl ester;2-(HydroxyMethyl)-2-phenyl-hydracrylic Acid 3α-Tropanyl Ester;1αH,5αH-Tropan-3α-ol, 2-(hydroxymethyl)-2-phenylhydracylate (ester) (8CI);α-Hydroxymethyl Atropine;1αH,5αH-Tropan-3α-ol, 2-(hydroxymethyl)-2-phenylhydracylate (ester);Atropine Impurity 45;rel-(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-(hydroxymethyl)-2-phenylpropanoate;a-Hydroxymethyl Atropine | | CAS: | 2515-36-8 | | MF: | C18H25NO4 | | MW: | 319.4 | | EINECS: | | | Product Categories: | Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 2515-36-8.mol | ![α,α-Bis(hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3α-yl ester Structure](CAS/GIF/2515-36-8.gif) |
| | α,α-Bis(hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3α-yl ester Chemical Properties |
| Boiling point | 489.2±45.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | solubility | DMF: 2 mg/ml; DMSO: 10 mg/ml; Ethanol: 16 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | pka | 13.14±0.10(Predicted) |
| | α,α-Bis(hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3α-yl ester Usage And Synthesis |
| Description | α-Hydroxymethyl atropine is a byproduct in the synthesis of atropine. It reduces acetylcholine-induced contractile activity of isolated rat intestine when used at a concentration of 0.025 ng/ml. | | Uses | Byproduct produced in the preparation of Atropine. | | References | [1] CHUNHUI DAI. Continuous-Flow Synthesis and Purification of Atropine with Sequential In-Line Separations of Structurally Similar Impurities[J]. Journal of Flow Chemistry, 2015, 5 3: 133-138. DOI: 10.1556/1846.2015.00013
[2] VENIERO SCARSELLI Giulio M Giorgio Cignarella. Structural Changes and Anticholinergic Activity in a Class of Tropic and α-Methyltropic Acid Derivatives[J]. Journal of Medicinal Chemistry, 1964, 7 2: 237-238. DOI: 10.1021/jm00332a026 |
| | α,α-Bis(hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3α-yl ester Preparation Products And Raw materials |
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