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4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID

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Products Intro: Product Name:NSC 133723
CAS:19741-14-1
Purity:98% HPLC LCMS Package:10G;20G
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Products Intro: Product Name:4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID
CAS:19741-14-1
Purity:0.98 Package:1KG;10KG;50KG
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Products Intro: Product Name:Methotrexate EP Impurity E
CAS:19741-14-1
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Products Intro: Product Name:4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID
CAS:19741-14-1
Purity:98% Package:1KG;3USD
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Products Intro: Product Name:Methotrexate metabolite
CAS:19741-14-1
Purity:99.7% Package:50mg;77USD|100mg;116USD|25mg;48USD Remarks:REAGENT;FOR LABORATORY USE ONLY

4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID manufacturers
4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Basic information
Product Name:4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID
Synonyms:2,4-Diamino-N(10)-methylpteroic acid;4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoic acid;Deoxyaminopteroic acid;N-10-Methyl-4-deoxy-4-aminopteroate;Nsc 131463;DAMPA;p-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid;4-[N-[(2,4-DiaMinopyriMido[4,5-b]pyrazin-6-yl)Methyl]-N- MethylaMino]benzoic Acid
CAS:19741-14-1
MF:C15H15N7O2
MW:325.33
EINECS:
Product Categories:Bases & Related Reagents;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;API
Mol File:19741-14-1.mol
4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Structure
4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Chemical Properties
Melting point 255 °C (dec.)(lit.)
Boiling point 689.3±65.0 °C(Predicted)
density 1.532
storage temp. 2-8°C(protect from light)
solubility Aqueous Base, DMSO
pka4.63±0.10(Predicted)
form Solid
color Dark Yellow to Very Dark Brown
Stability:Hygroscopic
Major Applicationpharmaceutical (small molecule)
InChI1S/C15H15N7O2/c1-22(10-4-2-8(3-5-10)14(23)24)7-9-6-18-13-11(19-9)12(16)20-15(17)21-13/h2-6H,7H2,1H3,(H,23,24)(H4,16,17,18,20,21)
InChIKeyLWCXZSDKANNOAR-UHFFFAOYSA-N
SMILESN(Cc2nc3c(nc(nc3N)N)nc2)(C)c1ccc(cc1)C(=O)O
CAS DataBase Reference19741-14-1
Safety Information
Hazard Codes Xi
Risk Statements 43-52/53
Safety Statements 36/37
WGK Germany 3
Storage Class6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard ClassificationsAcute Tox. 3 Oral
Eye Irrit. 2
Muta. 2
Repr. 1B
Skin Irrit. 2
MSDS Information
4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Usage And Synthesis
Chemical PropertiesBrownish Yellow to Orange Solid
UsesDAMPA is a Methotrexate (M260675) analog (1). DAMPA is an antitumor agent (2).
in vivo

Methotrexate metabolite (8.6-10.1 mg/kg, 200 mg/m2, i.v., 15 minutes) has pharmacokinetic properties of rapid clearance and extensive metabolism in adult male Rhesus monkeys (Macaca mulatta) (8.0-15.9 kg), with an average clearance rate of 1.9 l/kg/h and an average terminal half-life of 51 minutes[1].

4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Preparation Products And Raw materials
Preparation ProductsMethotrexate α-tert-Butyl Ester
Tag:4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID(19741-14-1) Related Product Information
Methotrexate γ-Methyl Ester Methotrexate Aminopterin Methotrexate α-Methyl Ester Methotrexate impurity N-(p-Aminobenzoyl)glutamic acid 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE L-Glutamic acid, N-[N-[N-[N-[4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-.gamma.-gluta myl]-L-.gamma.-glutamyl]-L-.gamma.-glutamyl]- Folic Acid Related Compound A/Calcium Formyltetrahydrofolate L-Glutamic acid der. 7-HYDROXY METHOTREXATE 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID 4-Dimethylaminobenzoic acid 6-Methyl-2,4-pteridinediamine 4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT 2,4-Diaminopteridine 4-Pteridinamine (9CI) 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO]BENZOIC ACID HEMIHYDROCHLORIDE HYDRATE