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| | Isotanshinone IIA Basic information |
| Product Name: | Isotanshinone IIA | | Synonyms: | 1,2,3,4-Tetrahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione;Isotanshinone II (Salvia miltiorhiza);Isotanshinone II;iso-Tanshinone II;Isotanshinone IIA;Phenanthro[3,2-b]furan-7,11-dione, 1,2,3,4-tetrahydro-4,4,8-trimethyl- | | CAS: | 20958-15-0 | | MF: | C19H18O3 | | MW: | 294.34 | | EINECS: | | | Product Categories: | | | Mol File: | 20958-15-0.mol |  |
| | Isotanshinone IIA Chemical Properties |
| Melting point | 208 °C | | Boiling point | 471.1±45.0 °C(Predicted) | | density | 1.209±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | powder | | color | Red |
| | Isotanshinone IIA Usage And Synthesis |
| Uses | Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. | | References | [1] Han YM, et al. PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza. Biol Pharm Bull. 2005 Sep;28(9):1795-7. DOI:10.1248/bpb.28.1795 |
| | Isotanshinone IIA Preparation Products And Raw materials |
| Raw materials | 2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-7-[(1R)-2-hydroxy-1-methylethyl]-1,1-dimethyl-, (4aR,9S,10aS)- |
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