- Diethyl ketomalonate
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- $0.00 / 25KG
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2025-08-13
- CAS:609-09-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- Diethyl ketomalonate
-
- $10.00 / 1KG
-
2025-06-24
- CAS:609-09-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100 mt
- Diethyl ketomalonate
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- $0.00 / 1KG
-
2022-02-19
- CAS:609-09-6
- Min. Order: 1KG
- Purity: 98.7%
- Supply Ability: 100 tons
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| | Diethyl ketomalonate Basic information |
| Product Name: | Diethyl ketomalonate | | Synonyms: | 2-Oxopropanedioic acid diethyl;2-Oxopropanedioic acid diethyl ester;Ketomalonic acid diethyl;Oxomalonic acid diethyl;Diethyl KETOMALONATE ester;Diethyl ketomalonate ,98%;Diethyl 2-oxomalonate 97%;Diethyl ketomalonate, (Diethyl mesoxalate | | CAS: | 609-09-6 | | MF: | C7H10O5 | | MW: | 174.15 | | EINECS: | 210-176-2 | | Product Categories: | Pharmaceutical Intermediates | | Mol File: | 609-09-6.mol |  |
| | Diethyl ketomalonate Chemical Properties |
| Hazard Codes | Xi | | Safety Statements | 24/25 | | WGK Germany | 3 | | F | 21 | | Hazard Note | Irritant | | TSCA | T | | HazardClass | IRRITANT, MOISTURE SENSITIVE | | HS Code | 29183000 |
| | Diethyl ketomalonate Usage And Synthesis |
| Chemical Properties | Clear yellow liquid | | Uses | Diethyl ketomalonate, reagent employed in Wittig and Aza-Wittig reactions for synthesis of triazoles, and 2-azadienes, respectively. | | Application | Diethyl ketomalonate can be used in electron-deficient heterodienophile; Diels-Alder reaction; heterodipolarophile; [3 + 2] cycloaddition; 1,3-diyl trapping agent; 1,4-dipolar cycloaddition; [2 + 2] cycloaddition; enophile; ene reaction; electrophilic addition; Wittig reactions; condensation with amines; Pictet-Spengler reactions. | | Preparation | Diethyl ketomalonate can be prepared by bromination of Diethyl Malonate to the dibromomalonic ester, exchange of one bromine atom for acetate and α-elimination of acetyl bromide. Alternatively, diethyl malonate is condensed with benzaldehyde to afford the Knoevenagel product which is cleaved by ozonolysis. | | Synthesis Reference(s) | Synthetic Communications, 24, p. 695, 1994 DOI: 10.1080/00397919408012648
The Journal of Organic Chemistry, 46, p. 2598, 1981 DOI: 10.1021/jo00325a039 | | Synthesis | The general procedure for the synthesis of diethyl ketomalonate from diethyl methylidenemalonate was as follows: 258 g of diethyl methylidenemalonate prepared by Knoevenagel condensation reaction of malonic acid and formaldehyde was dissolved in 1 liter of methanol, followed by ozonation reaction. Upon completion of the reaction, 5 g of 10% Pd-on-C was added as a hydrogenation catalyst and placed in 200 ml of methanol to carry out the hydrogenation reaction, with a hydrogen consumption of 28.9 standard liters (86% of the theoretical value was reached). The reaction mixture was post-treated according to the method of Example 5 and subsequently concentrated under vacuum to give 214 g of diethyl ketomalonate with a boiling point of 10.0-112°C/20 mmHg in 82% yield of the theoretical value. | | storage | Diethyl ketomalonate is stable for at least 6 months if stored in the refrigerator. | | References | [1] Patent: US4769464, 1988, A
[2] Tetrahedron Letters, 1981, vol. 22, # 46, p. 4607 - 4610 |
| | Diethyl ketomalonate Preparation Products And Raw materials |
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