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4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid

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CAS:5623-18-7
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Products Intro: Product Name:4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl)amino}benzoic acid
CAS:5623-18-7
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CAS:5623-18-7
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4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Basic information
Product Name:4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid
Synonyms:p-[(2-Amino-4-hydroxy-6-pteridinyl)methyl(methyl)amino]benzoic acid;N10-Methyl Pteroic Acid;4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoic Acid;Metfol-B;NSC 408937;4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino}benzoic acid;Methotrexate EP Impurity D;Methotrexate Impurity 4(EP-D)
CAS:5623-18-7
MF:C15H14N6O3
MW:326.31
EINECS:
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:5623-18-7.mol
4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Structure
4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Chemical Properties
Melting point >245°C (dec.)
Boiling point 583.7±60.0 °C(Predicted)
density 1.58±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Aqueous Base (Slightly), DMSO (Very Slightly, Heated), Methanol (Very Slightly)
pka4.74±0.10(Predicted)
color Orange to Red
Major Applicationpharmaceutical (small molecule)
InChI1S/C15H14N6O3/c1-21(10-4-2-8(3-5-10)14(23)24)7-9-6-17-12-11(18-9)13(22)20-15(16)19-12/h2-6H,7H2,1H3,(H,23,24)(H3,16,17,19,20,22)
InChIKeyQHNLFEQJGRZKTK-UHFFFAOYSA-N
SMILES[nH]1c2nc(n[c](c2nc(c1)CN(C)c3ccc(cc3)C(=O)O)=O)N
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Usage And Synthesis
Chemical PropertiesDark Orange Solid
UsesN10-Methyl Pteroic Acid (Methotrexate EP Impurity D) is a Methotrexate (M260675) impurity D.
UsesMethotrexate (M260675) impurity D.
4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Preparation Products And Raw materials
Raw materials4-(Methylamino)benzoic acid-->6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE-->3,5-DI-T-BUTYL-4-METHOXYBENZALDEHYDE-->4-Aminobenzoic acid
Tag:4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid(5623-18-7) Related Product Information
7-HYDROXY METHOTREXATE METHOTREXATE DIMETHYL ESTER Methotrexate Related Compound E (50 mg) (4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid, hemihydrochloride) Methotrexate γ-Methyl Ester Methotrexate α-Methyl Ester METHOTREXATE-D3 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Methotrexate L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]- methotrexate-gamma-dimethylamide N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Aminopterin Methotrexate EP Impurity G D(-)-AMETHOPTERIN L-Glutamic acid der. Folic Acid Related Compound A/Calcium Formyltetrahydrofolate