|
|
| | 3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide Basic information |
| | 3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide Chemical Properties |
| | 3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide Usage And Synthesis |
| Uses | 3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL)[1]. | | References | [1] He X, Tang J, Qiao A, et al. Cytotoxic biotransformed products from cinobufagin by Mucor spinosus and Aspergillus Niger[J]. Steroids, 2006, 71(5): 392-402. |
| | 3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide Preparation Products And Raw materials |
|