| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Cyclic adenosine diphosphate-ribose
CAS:119340-53-3
Purity:>=90% (HPLC) Package:250μg, 0.5mg Remarks:C7344
|
|
| | CADP-RIBOSE Basic information |
| Product Name: | CADP-RIBOSE | | Synonyms: | cyclicadenosinediphosphateribose(cadpr),sodiumsalt;CYCLIC ADP RIBOSE POTENT INTRACELLULAR;ADP-cyclo[N1:1μμ]-ribose, cADP-ribose, cADPR, Cyclic ADPR;C13050;cADP-Ribose (cADPR);N-ALPHA-D-RIOFURANOSYL-P',5''-ESTER ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE);CYCLIC ADENOSINE 5'-DIPHOSPHATE RIBOSE;CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE | | CAS: | 119340-53-3 | | MF: | C15H21N5O13P2 | | MW: | 541.3 | | EINECS: | | | Product Categories: | | | Mol File: | 119340-53-3.mol |  |
| | CADP-RIBOSE Chemical Properties |
| Boiling point | 934.8±75.0 °C(Predicted) | | density | 2.57±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO (Slightly), Methanol (Very Slightly), Water (Slightly) | | form | lyophilized powder | | pka | 0.97±0.70(Predicted) | | color | White to off-white | | biological source | (Ovotestis from sea hare) | | Stability: | Hygroscopic | | Cosmetics Ingredients Functions | SKIN CONDITIONING
HAIR CONDITIONING
SKIN PROTECTING |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | CADP-RIBOSE Usage And Synthesis |
| Uses | Cyclic adenosine diphosphate-ribose (cADPR) is an intracellular second messenger that mobilizes intracellular Ca2+ release from the sarcoplasmic reticulum through ryanodine receptors. CADPR is also a second messenger for glucose-induced insulin release from endocrine pancreas and for abscisic acid-induced calcium release in plants. | | Definition | ChEBI: A cyclic purine nucleotide that is synthesised from NAD+ by ADP-ribosyl cyclase; acts as an agonist at ryanodine receptors. | | Biochem/physiol Actions | Mobilizes intracellular Ca2+; regulates Ca2+-induced Ca2+?release specifically blocked by ryanodine; second messenger for glucose-induced insulin release from the endocrine pancreas and for abscisic acid-induced calcium release in plants. | | in vivo | cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5]. |
| | CADP-RIBOSE Preparation Products And Raw materials |
|