8-METHYL-2,4-DICHLOROQUINAZOLINE manufacturers
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| | 8-METHYL-2,4-DICHLOROQUINAZOLINE Basic information |
| | 8-METHYL-2,4-DICHLOROQUINAZOLINE Chemical Properties |
| Boiling point | 292℃ | | density | 1.418 | | Fp | 158℃ | | storage temp. | Inert atmosphere,Room Temperature | | pka | -0.20±0.30(Predicted) | | Appearance | White to light yellow Solid |
| | 8-METHYL-2,4-DICHLOROQUINAZOLINE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2,4-dichloro-8-methylquinazoline from 2,4-dihydroxy-8-methylquinazoline was as follows: 8-methylquinazoline-2,4(1H,3H)-dione (4.50 g, 25.50 mmol) was added to phosphorochloridic acid (47.6 mL, 510.9 mmol). The reaction mixture was stirred at 100 °C for 6 h and subsequently cooled to room temperature. The reaction solution was slowly poured into water (300 mL) and the internal temperature was controlled to be below 60°C. After precipitating the solid, the product was collected by filtration to afford 2,4-dichloro-8-methylquinazoline (4.30 g, 79% yield). | | References | [1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 254 - 259
[2] Patent: US5064833, 1991, A
[3] Patent: EP322133, 1991, B1
[4] Patent: EP322133, 1989, A1
[5] Synthesis (Germany), 2016, vol. 48, # 8, p. 1226 - 1234 |
| | 8-METHYL-2,4-DICHLOROQUINAZOLINE Preparation Products And Raw materials |
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