| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
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Product Name:CAY10580
CAS:64054-40-6
Purity:>=96% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CAY10580
CAS:64054-40-6
Purity:96% Package:1G;10G;100G Remarks:Prostaglandin E2 is a naturally occurring prostaglandin which is used as a medication. As a medication it is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:CAY10580
CAS:64054-40-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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marketing@energy-chemical.com |
| Products Intro: |
Product Name:2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoicacid
CAS:64054-40-6
Purity:NULL Package:1000g;500g Remarks:NULL
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 15002144251 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CAY10580
CAS:64054-40-6
Package:10mg/RMB 24500;1mg/RMB 3360;5mg/RMB 13900
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| | CAY10580 Basic information |
| Product Name: | CAY10580 | | Synonyms: | 2-(3-HYDROXYOCTYL)-5-OXO-1-PYRROLIDINEHEPTANOIC ACID;CAY10580;CAY10580 Exclusive;CBWGHEDGUILASE-UHFFFAOYSA-N;1-Pyrrolidineheptanoic acid, 2-(3-hydroxyoctyl)-5-oxo- | | CAS: | 64054-40-6 | | MF: | C19H35NO4 | | MW: | 341.49 | | EINECS: | | | Product Categories: | | | Mol File: | 64054-40-6.mol |  |
| | CAY10580 Chemical Properties |
| Boiling point | 534.4±25.0 °C(Predicted) | | density | 1.049±0.06 g/cm3(Predicted) | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 2.5 mg/ml | | pka | 4.77±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | CAY10580 Usage And Synthesis |
| Uses | Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively). CAY10580 stimulates cAMP formation in excised mouse ovaries.[Cayman Chemical] | | Uses | 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is an analog of PGE2. | | Definition | ChEBI: 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is a pyrrolidin-2-one substituted by 6-carboxyhexyl and 3-hydroxyoctyl groups at positions 1 and 2, respectively. It is a potent prostaglandin EP4 receptor agonist (Ki=35 nM). It has a role as a prostaglandin receptor agonist. It is a member of pyrrolidin-2-ones, a hydroxy monocarboxylic acid and a secondary alcohol. | | in vivo | CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion[3]. | Animal Model: | Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)[3] | | Dosage: | 200 μg/kg body weight | | Administration: | Intraperitoneal injection; daily for remaining three weeks | | Result: | High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.
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| | IC 50 | EP4: 35 nM (Ki); EP2: 3000 nM (Ki); EP3: 2000 nM (Ki); EP1: >3000 nM (Ki) |
| | CAY10580 Preparation Products And Raw materials |
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