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| | 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone Basic information |
| Product Name: | 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone | | Synonyms: | 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl);-yl}ethan-1-one;Ethanone, 1-(6'-aminospiro[cyclopropane-1,3'-[3H]indol]-1'(2'H)-yl)-;1-{6'-amino-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-1'-yl}ethan-1-one;1-(6'-aminospiro[cyclopropane-1,3'-indoline]-1'-yl)ethanone;1-(6'-aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone;1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone - [A14989];1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone | | CAS: | 645419-13-2 | | MF: | C12H14N2O | | MW: | 202.25 | | EINECS: | | | Product Categories: | | | Mol File: | 645419-13-2.mol | ![1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone Structure](CAS/GIF/645419-13-2.gif) |
| | 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone Chemical Properties |
| Boiling point | 488.1±45.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 4.06±0.20(Predicted) |
| | 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 1-(6'-aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone from the compound (CAS: 645419-12-1) was as follows: 1-acetyl-6-nitro-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole (383 mg, 2 mmol) was mixed with Pd-C (10%, 100 mg) The mixture in EtOH (50 mL) was stirred at room temperature for 1.5 h in H2 (1 atm) atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was treated with HCl/MeOH solution to afford 1-acetyl-6-amino-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole (DC-2) (300 mg, 90% yield) in the form of hydrochloride. | | References | [1] Patent: US2011/98311, 2011, A1
[2] Patent: US2012/309758, 2012, A1
[3] Patent: WO2004/5279, 2004, A2. Location in patent: Page 170-171 |
| | 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone Preparation Products And Raw materials |
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