| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
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| | D-69491 Basic information |
| Product Name: | D-69491 | | Synonyms: | 5-[[4-[(3-Chloro-4-fluorophenyl)amino]-6,7-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide hydrochloride;D-69491;SU-11464;D69491; SU 11464; SU11464; D 69491;5-[[4-[(3-Chloro-4-fluorophenyl)amino]-6,7-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-m;D-69491 hydrochloride | | CAS: | 346599-65-3 | | MF: | C25H26Cl2FN7O3 | | MW: | 562.43 | | EINECS: | | | Product Categories: | | | Mol File: | 346599-65-3.mol |  |
| | D-69491 Chemical Properties |
| | D-69491 Usage And Synthesis |
| Uses | D-69491 hydrochloride is a HER-2 tyrosine kinase inhibitor that reduces HER-2 phosphorylation, inhibits the proliferation of SKOV-3 cells, and has anticancer activity[1]. | | IC 50 | HER2 | | References | [1] Shaker Abuharbeid, et al. Inhibition of HER-2 by three independent targeting strategies increases paclitaxel resistance of SKOV-3 ovarian carcinoma cells. Naunyn Schmiedebergs Arch Pharmacol. 2005 Feb;371(2):141-51. DOI:10.1007/s00210-004-1016-4 |
| | D-69491 Preparation Products And Raw materials |
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