1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride

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1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride Basic information
Product Name:1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride
Synonyms:5-(piperazin-1-ylsulfonyl)isoquinoline hydrochloride;Fasudil Impurity 22 HCl;HA 100 dihydrochloride, Myosin light chain kinase, PKA, PKC and PKG inhibitor;HA 100 dihydrochloride (mM/ml), MYLK, PKA, PKC and PKG inhibitor
CAS:141543-63-7
MF:C13H16ClN3O2S
MW:313.8
EINECS:
Product Categories:Heterocycles;Inhibitors;Protein Kinase Inhibitors and Activators;Sulfur & Selenium Compounds
Mol File:141543-63-7.mol
1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride Structure
1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride Chemical Properties
Melting point 252-254°C
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly), Water
form Solid
color Off-White to Light Yellow
Safety Information
MSDS Information
1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride Usage And Synthesis
Chemical PropertiesPale Yellow Solid
UsesHA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].
IC 50PKG: 4 μM (IC50); PKA: 8 μM (IC50); PKC: 12 μM (IC50); MLCK: 240 μM (IC50); ROCK
References[1] Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. PMID:2955213
[2] Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557. DOI:10.1371/journal.pone.0017557
1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride Preparation Products And Raw materials
Tag:1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride(141543-63-7) Related Product Information
Fasudil Hydrochloride Hydrate {2-[4-(Pyridin-3-ylsulfonyl)piperazin-1-yl]ethyl}amine HA-1004 (hydrochloride) 5-(4-Methylpiperazin-1-ylsulfonyl)-1H-indole 4-(1-piperazinylsulfonyl)benzenesulfonamide 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride