MK-5582

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MK-5582 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:SSTR5 antagonist 2
CAS:1254730-81-8
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:SSTR5 antagonist 2
CAS:1254730-81-8
Package:25mg;1810USD|50mg;2470USD|100mg;3090USD
Company Name: TargetMol Chemicals Inc.
Tel: 13564774135
Email: marketing@targetmol.com
Products Intro: Product Name:SSTR5 antagonist 2
CAS:1254730-81-8
Package:25mg;1670USD|50mg;2180USD|100mg;2800USD
Company Name: Shanghai Yaocheng Pharmaceutical Technology Partnership (Limited Partnership)  Gold
Tel: 400-6181121 18616381138
Email: runran.li@townyuan.com
Products Intro: Product Name:4-[8-[(2,6-Diethoxy-4′-fluoro[1,1′-biphenyl]-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl]benzoic acid
CAS:1254730-81-8
Purity:98 Package:1g；10g；25g；100g
Company Name: ShangHai Onsyn-Chemical Technology Co., Ltd.  
Tel: 13917628136 15900795984
Email: 572350448@qq.com
Products Intro: Product Name:4-{8-[(2,6-diethoxy-4'-fluorobiphenyI-4-yl)Methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid
CAS:1254730-81-8
Purity:98% Package:10Mg, 100Mg, 10g

MK-5582 manufacturers
MK-5582 Basic information
Product Name:MK-5582
Synonyms:MK-5582;4-(8-((2,6-diethoxy-4'-fluoro-[1,1'-biphenyl]-4-yl)Methyl)-3-oxo-2,8-diazaspiro[4.5]decan-2-yl)benzoic acid;4-{8-[(2,6-diethoxy-4'-fluorobiphenyI-4-yl)Methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid;SSTR5 antagonist 2;Benzoic acid, 4-[8-[(2,6-diethoxy-4'-fluoro[1,1'-biphenyl]-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl]-;SSTR5 antagonist 2,SSTR-5 antagonist 2;4-[8-({2,6-diethoxy-4'-fluoro-[1,1'-biphenyl]-4-yl}methyl)-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid;4-(8-((2,6-diethoxy-4'-fluoro-[1,1'-biphenyl]-4-yl)methyl)-3-oxo-2,8-diazaspiro[4.5]dec-2-yl)benzoic acid
CAS:1254730-81-8
MF:C32H35FN2O5
MW:546.63
EINECS:
Product Categories:
Mol File:1254730-81-8.mol
MK-5582 Structure
MK-5582 Chemical Properties
Boiling point 710.2±60.0 °C(Predicted)
density 1.30±0.1 g/cm3(Predicted)
pka4.34±0.10(Predicted)
Safety Information
MSDS Information
MK-5582 Usage And Synthesis
UsesSSTR5 antagonist 2 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM)[1].
in vivo

SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1].
SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1].

Animal Model:Rodent diabetic model without risk of hypoglycemia[1].
Dosage:10 mg/kg.
Administration:Orally.
Result:Increased both total and active circulating incretin hormone GLP1 levels.
References[1] Liu W, et al. Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett. 2018 Sep 12;9(11):1082-1087. DOI:10.1021/acsmedchemlett.8b00305
MK-5582 Preparation Products And Raw materials
Tag:MK-5582(1254730-81-8) Related Product Information
Pasireotide Lanreotide acetate SOMATOSTATIN 28, CYCLIC CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) DOTA-NOC, DOTA-[Nal3]-octreotide D-Tyrosinamide, 4-chloro-N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-L-phenylalanyl-D-cysteinyl-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]-L-phenylalanyl-4-[(aminocarbonyl)amino]-D-phenylalanyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide