(2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE
生物活性靶点体外研究体内研究 用途与合成方法 MSDS (2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE价格(试剂级) 上下游产品信息
| 中文名称 | (2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE |
|---|---|
| 中文同义词 | (2S)-2-(4-吡啶甲基氨基)-1-(6,7-二甲氧基-1,2,3,4-四氢异喹啉-2-基)-3,3-二甲基丁烷-1-酮;化合物TCS-OX2-29;TCS OX2 29,OREXIN-2受体拮抗剂;TCS OX2 29,OREXIN-2 RECEPTOR拮抗剂;化合物TCS-OX2-29,10 MM DMSO 溶液;TCS-OX2-29试剂;TCS-OX2-29试剂 |
| 英文名称 | (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride |
| 英文同义词 | (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride;TCS OX2 29;(2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE;TCS-OX2-29, CID 10408514;1-Butanone, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-, (2S)-;(S)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3,3-dimethyl-2-((pyridin-4-ylmethyl)amino)butan-1-one;TCS OX2 29, Orexin-2 receptor antagonist;TCS-OX2-29, 10 mM in DMSO |
| CAS号 | 372523-75-6 |
| 分子式 | C23H31N3O3 |
| 分子量 | 397.51 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 372523-75-6.mol |
| 结构式 |  |
(2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE 性质
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
|---|---|
| 溶解度 | DMSO : 25 mg/mL (62.89 mM; 需要超声) 乙醇 : 25 mg/mL (62.89 mM; 需要超声) H2O : < 0.1 mg/mL (不溶) |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
| 水溶解性 | H2O: ≥2.0mg/mL, clear |
| InChI | 1S/C23H31N3O3/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3/t21-/m1/s1 |
| InChIKey | COFVZFLCAOUMJT-OAQYLSRUSA-N |
| SMILES | N2(CCc3c(cc(c(c3)OC)OC)C2)C(=O)[C@@H](NCc1ccncc1)C(C)(C)C |
(2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE 用途与合成方法
TCX-OX2-29是OX2R 拮抗剂，pKi=7.5。对hOX2R的选择性比hOX1R高250倍以上，IC50分别为40 nM和>10000 nM。
IC50: 40 nM ( OX 2 R ); pKi: 7.5 ( OX 2 R )
TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX 2 receptor.
TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both naïve and dependent mice significantly.
| Animal Model: | 440 adult male NMRI mice (25-30 g) |
| Dosage: | 5 mg/kg and 10 mg/kg |
| Administration: | Intraperitoneal injection (Pharmacokinetic study) |
| Result: | Suppressed conditioned place preference (CPP) acquisition and expression in both naïve and dependent mice significantly. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100452 | (2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE TCS-OX2-29 | 372523-75-6 | 5mg | 800元 |
| 2026/06/05 | HY-100452 | (2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE TCS-OX2-29 | 372523-75-6 | 10mM * 1mLin DMSO | 880元 |