2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoicacid
| 中文名称 | 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoicacid |
|---|---|
| 中文同义词 | 化合物 T22686;化合物 CP 775146 |
| 英文名称 | 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoicacid |
| 英文同义词 | 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoicacid;CP 775146;(S)-2-[3-[1-[(4-Isopropylphenyl)acetyl]piperidin-3-yl]phenoxy]-2-Methylpropionic Acid;2-Methyl-2-[3-[(3S)-1-[[4-(1-Methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]propanoic Acid;PF-06340672;(S)-2-(3-(1-(2-(4-isopropylphenyl)acetyl)piperidin-3-yl)phenoxy)-2-methylpropanoic acid;Propanoic acid, 2-methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-;Troglitazone-d |
| CAS号 | 702680-17-9 |
| 分子式 | C26H33NO4 |
| 分子量 | 423.54 |
| EINECS号 | |
| 相关类别 | Agonists;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pfizer Compounds;Pharmaceuticals |
| Mol文件 | 702680-17-9.mol |
| 结构式 | ![2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoicacid 结构式](CAS/GIF/702680-17-9.gif) |
2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoicacid 性质
| 熔点 | >70°C (dec.) |
|---|---|
| 储存条件 | Store at RT |
| 溶解度 | 二甲基亚砜：≥80mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至棕褐色 |
| 旋光度 (Optical Rotation) | [α]/D -75 to -83° in methanol |
| InChIKey | YQAGREGJJZRFDN-VZYDHVRKSA-M |
| SMILES | CC(C)C1=CC=C(CC(N2CCC[C@@H](C3=CC(OC(C)(C)C(O)=O)=CC=C3)C2)=O)C=C1 |
2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoicacid 用途与合成方法
CP-775146 是一种新的选择性 PPARα 激动剂，与 PPARα 配体强烈结合。CP-775146 有效缓解肥胖引起的肝损伤，通过激活肝脏脂肪酸 β-氧化途径防止脂质积累。