- (R)-Pregabalin
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- $28.00 / 1KG
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2022-02-25
- CAS:148553-51-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1 ton
- (R)-Pregabalin
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- $11.36 / 1KG
-
2022-02-25
- CAS:148553-51-9
- Min. Order: 1Kg/Bag
- Purity: 99%
- Supply Ability: 3tons
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| | Hexanoic acid,3-(aminomethyl)-5-methyl-, (3R)- Basic information |
| | Hexanoic acid,3-(aminomethyl)-5-methyl-, (3R)- Chemical Properties |
| Boiling point | 274.0±23.0 °C(Predicted) | | density | 0.997±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Methanol (Slightly), Water (Slightly) | | form | Solid | | pka | 4.23±0.10(Predicted) | | color | White | | Major Application | pharmaceutical | | InChI | 1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m1/s1 | | InChIKey | AYXYPKUFHZROOJ-SSDOTTSWSA-N | | SMILES | [N+H3]C[C@H](CC(C)C)CC(=O)[O-] |
| WGK Germany | WGK 3 | | HS Code | 2922493800 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Repr. 2 STOT SE 3 |
| | Hexanoic acid,3-(aminomethyl)-5-methyl-, (3R)- Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | (R)-Pregabalin is a GABA analogue used as an anticonvulsant, Anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia (less potent than the S-Enantiomer). | | Synthesis | Hexanoic acid,3-(aminomethyl)-5-methyl-, (3R)- was synthesized by the resolution of racemic amide with (S)-1-phenylethylamine in chloroform and ethanol followed by Hofmann reaction[1].
 | | References | [1] Sripathi, S., Somesetti, N. R., Veeramalla, R., Challa, N. R., Peddi, S., Karnati, V. R. (2010). Synthesis and characterization of impurities of an anticonvulsant drug, Pregabalin. Arkivoc, 2010 1. https://doi.org/10.3998/ARK.5550190.0011.A22
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| | Hexanoic acid,3-(aminomethyl)-5-methyl-, (3R)- Preparation Products And Raw materials |
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