216691-95-1
| 中文名称 | 216691-95-1 |
|---|---|
| 中文同义词 | 化合物 T14846;化合物 BZ 423;化合物BZ 423,10 MM DMSO 溶液 |
| 英文名称 | 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one |
| 英文同义词 | 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one;Bz-423;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-Methyl-3-(2-naphthalenylMethyl)-;7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one;BZ48;Bz-423 >=98% (HPLC);Bz 423 (BZ48);Bz 423, 10 mM in DMSO |
| CAS号 | 216691-95-1 |
| 分子式 | C27H21ClN2O2 |
| 分子量 | 440.92 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 216691-95-1.mol |
| 结构式 |  |
216691-95-1 性质
| 沸点 | 697.2±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.28±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥ 125 mg/mL（283.50 mM） |
| 酸度系数(pKa) | 9.05±0.30(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
| InChI | 1S/C27H21ClN2O2/c1-30-25-13-10-21(28)16-23(25)26(19-8-11-22(31)12-9-19)29-24(27(30)32)15-17-6-7-18-4-2-3-5-20(18)14-17/h2-14,16,24,29H,15H2,1H3 |
| InChIKey | IJEUIRDNQUQMFU-UHFFFAOYSA-N |
| SMILES | ClC1=CC=C2C(C(C3=CC=C(O)C=C3)=NC(CC4=CC=C(C=CC=C5)C5=C4)C(N2C)=O)=C1 |
Bz 423 是一种促凋亡的1,4-苯并二氮平类化合物，能够活化 Bax 和 Bak，能用于红斑狼疮等自身免疫病的研究。
|
Bax
|
Bak
|
Bz-423 induces a larger superoxide response in Ramos cells, and causes rapid death of Ramos B cells. Bz-423 activates Bax and Bak, but does not activate ASK1/JNK in Ramos cells. In Ramos cells Bz-423-induced superoxide leads to Bax and Bak activation via changes in Mcl-1 expression and functional activation of BH3-only proteins. Bz-423 rapidly increases superoxide levels in MEFs within 1 h and the magnitude of the increase is concentration-dependent. Bz-423-induced apoptosis dependents upon superoxide.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-13108 | 216691-95-1 Bz 423 | 216691-95-1 | 5mg | 950元 |
| 2026/09/15 | HY-13108 | 216691-95-1 Bz 423 | 216691-95-1 | 10mM * 1mLin DMSO | 1045元 |