| Company Name: |
ACROBiosystems |
| Tel: |
13121935750 |
| Email: |
jiaxin.zhao@acrobiosystems.com |
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| Product Name: | PLEIOTROPHIN, HUMAN | | Synonyms: | RECOMBINANT HUMAN PLEIOTROPHIN;ANTI-ANKS4B (CENTER) antibody produced in rabbit;ANTI-PTN antibody produced in mouse;HUMAN OSTEOBLAST-SPECIFIC FACTOR;HUMAN PTN;HUMAN HEPARIN-BINDING GROWTH FACTOR-8;HUMAN HBGF8;HB-GAM (HUMAN) | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![PLEIOTROPHIN, HUMAN Structure]() |
| | PLEIOTROPHIN, HUMAN Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder | | biological source | rabbit |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 10 - Combustible liquids |
| | PLEIOTROPHIN, HUMAN Usage And Synthesis |
| Description | Pleiotrophin Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 136 amino acids and having a molecular mass of 15.3kDa.
The Pleiotrophin is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | Pleiotrophin (Osteoblast-Specific Factor-1, OSF-1) contains 136 amino acid residues. The sequence is very rich in cationic amino acids (24% of the residues); lysine cluster sequences are found in the N-terminal and C-terminal ends of the structure.
The OSF-1 gene was shown by Northern blotting analysis to be expressed in mouse calvarial osteoblast-enriched cells and in mouse brain tissues, but not in thymus, spleen, kidney, liver, lung, testis or heart. Pleiotrophin has the ability to promote adhesion, migration, expansion, and differentiation of human osteoprogenitor cells. In addition to certain types of cancer, the embryonic growth and differentiation factor pleiotrophin is found also in adults in inflammatory diseases. In osteoarthritis, pleiotrophin is especially expressed in early stages, and its concentrations in the synovial fluid could serve as a marker for the progress of the disease. Pleitrophin might be involved in cartilage repair in osteoarthritis, in particular, in earlier stages. |
| | PLEIOTROPHIN, HUMAN Preparation Products And Raw materials |
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