| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
|
| | 15-Lipoxygenase Inhibitor 1 Basic information |
| Product Name: | 15-Lipoxygenase Inhibitor 1 | | Synonyms: | 15-Lipoxygenase Inhibitor 1;15-Lipoxygenase Inhibitor I;15-Lipoxygenase Inhibitor 1 Exclusive;4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine;15-Lipoxygenase Inhibitor 1(4-MMPB);4-MMPB;15-Lipoxygenast Inhibitorl;LOX,4 MMPB,radical,Inhibitor,inhibit,4-MMPB,scavenging,Lipoxygenase,cancer,Apoptosis,4MMPB,inhibition | | CAS: | 928853-86-5 | | MF: | C16H19N5S | | MW: | 313.42 | | EINECS: | | | Product Categories: | | | Mol File: | 928853-86-5.mol |  |
| | 15-Lipoxygenase Inhibitor 1 Chemical Properties |
| Boiling point | 532.1±60.0 °C(Predicted) | | density | 1.265±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: >5mg/ml | | form | A crystalline solid | | pka | 7.17±0.42(Predicted) | | color | Light yellow to orange |
| | 15-Lipoxygenase Inhibitor 1 Usage And Synthesis |
| Uses | 4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer[1][2][3][4]. | | Biological Activity | 4-MMPB is a selective lipoxygenase 15-lipoxygenase inhibitor with IC50 value of 18 μM. The IC50 values of it against soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1) were 19.5 μM and 19.1 μM, respectively. It has potential for prostate cancer research. | | in vitro | 4-MMPB has an IC 50 of 69.6 μM for DPPH bleaching.
4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.
4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
Cell Viability Assay | Cell Line: | DU145 cells, PC-3 cells, HFF3 cells | | Concentration: | 9.57 μM, 19.94 μM, 39.88 μM, 79.77 μM, 159.53 μM | | Incubation Time: | 24 hours, 48 hours, 72 hours | | Result: | IC 50 s of 79.76 μM (24 hours), 51.05 μM (48 hours) and 41.48 μM (72 hours) for PC-3 cells, and 255.25 μM (24 hours), 130.81 μM (48 hours) and 98.91 μM (72 hours) for HFF3 cells. | | | target | IC50: 18 μM (15-lipoxygenase) | | References | [1] M Bakavoli, et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem. 2007 Mar 1;15(5):2120-6. DOI:10.1016/j.bmc.2006.12.022
[2] Mohsen Nikpour, et al. Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism. 2013, 22(10), 5036-5043.
[3] Seyed Jamal Alavi, et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018 Jun;91(6):1125-1132. DOI:10.1111/cbdd.13174
[4] Saffiyeh Saboormaleki, et al. 7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition. Arch Iran Med. 2018 Jun 1;21(6):251-259. PMID:29940744 |
| | 15-Lipoxygenase Inhibitor 1 Preparation Products And Raw materials |
|