| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:Epoxy Fluor 7
CAS:863223-43-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:Epoxy Fluor 7
CAS:863223-43-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:Epoxy Fluor 7
CAS:863223-43-2
Purity:98% Package:50mg; 1mg; 5mg; 10mg Remarks:Medbio
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:Epoxy Fluor 7
CAS:863223-43-2
Package:5mg/RMB 3150;10mg/RMB 5230;1mg/RMB 686
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:Epoxy Fluor 7 Exclusive
CAS:863223-43-2
Purity:98% Package:1mg;5mg;10mg
|
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| | Epoxy Fluor 7 Basic information |
| Product Name: | Epoxy Fluor 7 | | Synonyms: | Epoxy Fluor 7;Epoxy Fluor 7 Exclusive;[cyano-(6-methoxynaphthalen-2-yl)methyl] (3-phenyloxiran-2-yl)methyl carbonate;Carbonic acid, cyano(6-methoxy-2-naphthalenyl)methyl [(2R,3R)-3-phenyl-2-oxiranyl]methyl ester, rel-;Cyano(6-methoxy-2-napthalenyl)methyl[(2,3)-3-phenyloxiranyl]methyl ester | | CAS: | 863223-43-2 | | MF: | C23H19NO5 | | MW: | 389.4 | | EINECS: | | | Product Categories: | | | Mol File: | 863223-43-2.mol |  |
| | Epoxy Fluor 7 Chemical Properties |
| storage temp. | Store at -20°C,protect from light | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | Epoxy Fluor 7 Usage And Synthesis |
| Description | Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids (EpETrEs) to the corresponding DiHETrEs thereby diminishing their vasodilator activity.1 Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation.2,3 Epoxy fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used to monitor the activity of both human and mouse enzymes.4 Hydrolysis of the substrate epoxide yields a highly fluorescent product that can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. Epoxy fluor 7 is more stable in aqueous solution and offers about 2-fold better sensitivity than previously used colorimetric substrates such as NEPC.4 | | Uses | Epoxy Fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used for human and mouse enzymes. Epoxy Fluor 7 is hydrolyzed to yield fluorescence used for monitoring the activity of sEH. | | References | 1. Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids Circ. Res. 87(11),992-998(2000).
2. Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension Hypertension 46(2),975-981(2005).
3. Schmelzer, K.R., Kubala, L., Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation Proc. Natl. Acad. Sci. USA 102(28),9772-9777(2005).
4. Jones, P.D., Wolf, N.M., Morisseau, C., et al. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies Anal. Biochem. 343,66-75(2005). |
| | Epoxy Fluor 7 Preparation Products And Raw materials |
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