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| | 4-broMo-2-phenylthiazole Basic information |
| | 4-broMo-2-phenylthiazole Chemical Properties |
| Melting point | 65-67 °C | | Boiling point | 335.6±34.0 °C(Predicted) | | density | 1.563±0.06 g/cm3(Predicted) | | storage temp. | Store at room temperature | | pka | -0.34±0.10(Predicted) | | Appearance | Off-white to light yellow Solid |
| | 4-broMo-2-phenylthiazole Usage And Synthesis |
| Synthesis | Palladium(II) acetate (0.084 g, 0.38 mmol) was mixed with xantphos (0.220 g, 0.38 mmol) in 25 mL of tetrahydrofuran under nitrogen atmosphere. After stirring for 5 min, the resulting solution was transferred to a round-bottomed flask containing 2,4-dibromothiazole (3.64 g, 15 mmol), phenylboronic acid (1.96 g, 16 mmol) and potassium phosphate (9.55 g, 45 mmol). The reaction mixture was heated at 60 °C for 18 h, subsequently cooled to room temperature, filtered and washed with dichloromethane. The solvent was removed under reduced pressure to afford the crude product, which was purified by silica gel column chromatography using hexane:ethyl acetate as eluent to afford 4-bromo-2-phenylthiazole as a white solid (3 g, 84% yield).1H NMR (400 MHz, CDCl3) δ: 7.95 (dd, J = 3.4 Hz, 8.2 Hz, 2H), 7.47-7.46 (m 3H), 7.23 (s, 1H).LRMS (ESI) calculated value C9H6BrNS [M + H]+: 241.12, measured value: 241.00. | | References | [1] Patent: WO2015/191630, 2015, A1. Location in patent: Paragraph 00287
[2] Journal of Organic Chemistry, 2010, vol. 75, # 5, p. 1733 - 1739
[3] Patent: JP2018/140974, 2018, A. Location in patent: Paragraph 0067; 0068
[4] Patent: EP2455371, 2012, A1. Location in patent: Page/Page column 22
[5] Patent: US2013/296271, 2013, A1. Location in patent: Paragraph 0175 |
| | 4-broMo-2-phenylthiazole Preparation Products And Raw materials |
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