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Quality Control Solutions Ltd.
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Product Name:Busulfan Impurity 10
CAS:5539-53-7
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
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Shanghai Kewel Chemical Co., Ltd.
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Product Name:Busulfan Impurity 8
CAS:5539-53-7
Purity:95+ HPLC; Package:10mg;25mg;50mg;100mg
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TOSUN PHARM
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61855200 13326451905 |
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Product Name:Busulfan Impurity 6
CAS:5539-53-7
Purity:98%以上 Package:10mg;50mg;100mg等多种规格 Remarks:REF-B03009
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QUALITY CONTROL SOLUTIONS LTD.
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Product Name:Busulfan Impurity 8
Purity:95% HPLC Package:10MG;25MG;50MG;100MG
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Huaihua Yuanyanda Biotechnology Co., Ltd
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18711085600 |
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Product Name:Busulfan Impurity8
CAS:5539-53-7
Purity:98% HPLC Package:10mg;25mg;50mg;100mg
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| | acetyl Methanesulfonate Basic information |
| Product Name: | acetyl Methanesulfonate | | Synonyms: | acetyl Methanesulfonate;Methanesulfonyl acetate;NSC 158252;Busulfan Impurity 6;Acetic acid, anhydride with methanesulfonic acid;Busulfan Impurity 10 | | CAS: | 5539-53-7 | | MF: | C3H6O4S | | MW: | 138.14 | | EINECS: | | | Product Categories: | | | Mol File: | 5539-53-7.mol |  |
| | acetyl Methanesulfonate Chemical Properties |
| Boiling point | 56 °C(Press: 0.01 Torr) | | density | 1.346±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | Chloroform (Sparingly) | | form | Oil | | color | Yellow | | Stability: | Extremely Moisture Sensitive |
| | acetyl Methanesulfonate Usage And Synthesis |
| Uses | Acetyl Methanesulfonate, is an impurity of Busulfan (B689900), an alkylating agent with antileukemic activity. Antineoplastic. It is a reagent for ether cleavage, for the cleavage of activated cyclopropanes as partial structures of cyclopropyl ketones, and for acetylation of aromatic rings. | | Preparation | Preparative Methods: Acetyl Methanesulfonate can be prepared on a large scale (1 mol) from Acetyl Chloride and Methanesulfonic Acid by heating at reflux followed by fractional distillation (85% yield). | | storage | Handling, Storage, and Precautions: slightly hygroscopic. However, no particular precautions are required upon exposure to air for a short period of time. acetyl Methanesulfonate is stable if stored at 4 °C for several months. Use in a fume hood. | | Purification Methods | The main impurity is methanesulfonic acid. Reflux it with redistilled acetyl chloride for 6-10hours, i.e. until no further HCl is absorbed in a trap, and exclude moisture. Distil off excess of AcCl and carefully distil it below 0.001mm with the bath temperature below 120o to give the anhydride as a pale yellow oil which solidifies below 0o. Below ~130o it gives the disulfonic anhydride, and above ~130o polymers are formed, and it is used for cleaving ethers [Preparation, IR, NMR: Karger & Mazur J Org Chem 36 528, 532 1971]. [Beilstein 2 H 166, 2 III 349.] |
| | acetyl Methanesulfonate Preparation Products And Raw materials |
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