N-[3-(4,5-Dihydro-2-thiazolyl)-2-thiazolidinylidene]-5h dibenzo[a,d] cyclohepten-5-amine

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N-[3-(4,5-Dihydro-2-thiazolyl)-2-thiazolidinylidene]-5h dibenzo[a,d] cyclohepten-5-amine manufacturers

N-[3-(4,5-Dihydro-2-thiazolyl)-2-thiazolidinylidene]-5h dibenzo[a,d] cyclohepten-5-amine Basic information
Product Name:N-[3-(4,5-Dihydro-2-thiazolyl)-2-thiazolidinylidene]-5h dibenzo[a,d] cyclohepten-5-amine
Synonyms:N-(3-(4,5-Dihydrothiazol-2-yl)thiazolidin-2-ylidene)-5H-dibenzo[a,d][7]annulen-5-amine;N-(3-(4,5-Dihydrothiazol-2-yl)thiazolidin-2-ylidene)-5H-dibenzo[a,d][7]annulen-5-amine 97%;5H-Dibenzo[a,d]cyclohepten-5-amine, N-[3-(4,5-dihydro-2-thiazolyl)-2-thiazolidinylidene]-;ERRα antagonist 1;ERRα antagonist-1, 10 mM in DMSO;N-[3-(4,5-Dihydro-2-thiazolyl)-2-thiazolidinylidene]-5h dibenzo[a,d] cyclohepten-5-amine
CAS:1072145-33-5
MF:C21H19N3S2
MW:377.53
EINECS:
Product Categories:
Mol File:1072145-33-5.mol
N-[3-(4,5-Dihydro-2-thiazolyl)-2-thiazolidinylidene]-5h dibenzo[a,d] cyclohepten-5-amine Structure
N-[3-(4,5-Dihydro-2-thiazolyl)-2-thiazolidinylidene]-5h dibenzo[a,d] cyclohepten-5-amine Chemical Properties
Boiling point 579.0±60.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka4.98±0.10(Predicted)
form Solid
color White to off-white
Safety Information
HS Code 2934999090
MSDS Information
N-[3-(4,5-Dihydro-2-thiazolyl)-2-thiazolidinylidene]-5h dibenzo[a,d] cyclohepten-5-amine Usage And Synthesis
UsesERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1[1].
IC 50ERRα
References[1] Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related
N-[3-(4,5-Dihydro-2-thiazolyl)-2-thiazolidinylidene]-5h dibenzo[a,d] cyclohepten-5-amine Preparation Products And Raw materials
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