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| | 7H-Pyrrolo[2,3-d]pyriMidine, 4-iodo- Basic information |
| | 7H-Pyrrolo[2,3-d]pyriMidine, 4-iodo- Chemical Properties |
| density | 2.219±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 11.28±0.50(Predicted) | | Appearance | Off-white to gray Solid |
| | 7H-Pyrrolo[2,3-d]pyriMidine, 4-iodo- Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 4-iodo-7H-pyrrolo[2,3-d]pyrimidines from 4-chloro-7H-pyrrolo[2,3-d]pyrimidines is as follows: 4-chloro-7H-pyrrolo[2,3-d]pyrimidines were dissolved in 57 wt. % aqueous hydriodic acid. The reaction mixture was stirred at room temperature for 48 h. After completion of the reaction the insoluble solids were removed by filtration. The filtrate was diluted with cold water and the pH was adjusted with aqueous ammonia solution to 8. Subsequently, the precipitated solid product was collected by filtration, washed several times with deionized water and finally dried to obtain the target compound 4-iodo-7H-pyrrolo[2,3-d]pyrimidine. | | References | [1] ACS Combinatorial Science, 2015, vol. 17, # 1, p. 5 - 10
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5036 - 5046
[3] Patent: KR2016/124034, 2016, A. Location in patent: Paragraph 0054; 0055
[4] Patent: WO2009/9740, 2009, A1. Location in patent: Page/Page column 62
[5] Patent: EP2570125, 2013, A1. Location in patent: Paragraph 0154 |
| | 7H-Pyrrolo[2,3-d]pyriMidine, 4-iodo- Preparation Products And Raw materials |
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