5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE manufacturers
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| | 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Basic information |
| Product Name: | 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE | | Synonyms: | 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE;5-BROMO-4,6-DIMETHYL-2-HYDROXYPYRIDINE-3-CARBONITRILE;5-Bromo-3-cyano-2-hydroxy-4,6-dimethylpyridine, 98%;5-Bromo-2-hydroxy-4,6-dimethylpyridine-3-carbonitrile;5-BroMo-4,6-diMethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;5-Bromo-1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 5-bromo-1,2-dihydro-4,6-dimethyl-2-oxo-;5-bromo-4,6-dimethyl-2-oxo-1H-pyridine-3-carbonitrile | | CAS: | 23819-87-6 | | MF: | C8H7BrN2O | | MW: | 227.06 | | EINECS: | | | Product Categories: | | | Mol File: | 23819-87-6.mol |  |
| | 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Chemical Properties |
| Melting point | 263-266°C | | Boiling point | 301℃ | | density | 1.61 | | Fp | 136℃ | | storage temp. | Inert atmosphere,Room Temperature | | pka | 7.00±0.10(Predicted) | | Appearance | White to off-white Solid | | CAS DataBase Reference | 23819-87-6 |
| | 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Usage And Synthesis |
| Chemical Properties | White solid | | Synthesis | General procedure for the synthesis of 2-hydroxy-3-cyano-4,6-dimethyl-5-bromopyridine from 2-oxo-4,6-dimethyl-1,2-dihydropyridine-3-carbonitrile: To a solution of 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (35 g, 236 mmol) in acetic acid (200 ml) is added slowly and dropwise bromine (41.5 g, 260 mmol). 260 mmol). The reaction mixture was stirred at room temperature for 30 minutes. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The crude product was purified by recrystallization from ethanol-water mixed solvent to afford 5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (70 g, 95% yield). The product was analyzed by LCMS (Table 1, method c) showing retention time RT = 1.63 min; mass spectrum m/z = 226,228 (M + H). | | References | [1] Journal of Organic Chemistry, 1984, vol. 49, # 26, p. 5237 - 5243
[2] Patent: WO2016/198908, 2016, A1. Location in patent: Page/Page column 76
[3] Pharmaceutical Chemistry Journal, 1989, vol. 23, # 12, p. 983 - 986
[4] Khimiko-Farmatsevticheskii Zhurnal, 1989, vol. 23, # 12, p. 1459 - 1463
[5] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 2, p. 272 - 278 |
| | 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE Preparation Products And Raw materials |
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