| Company Name: |
Shanghai Kewel Chemical Co., Ltd.
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| Tel: |
021-64609169 18901607656 |
| Email: |
greensnown@163.com |
| Products Intro: |
Product Name:methyl 4-(methylamino)pyridine-2-carboxylate
CAS:1256817-30-7
Purity:95+ HPLC; Package:10mg;25mg;50mg;100mg
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| Company Name: |
Shanghai Synteam Biochem CO.,ltd
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| Tel: |
+86-021-58380978 13482386415 |
| Email: |
info@systeambc.com |
| Products Intro: |
Product Name:Sorafenib iMpurity
Purity:95.0% Package:25mg;100mg;250mg
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| | Sorafenib IMpurity Basic information |
| Product Name: | Sorafenib IMpurity | | Synonyms: | 4-(4-(3-(2-chloro-3-(trifluoroMethyl)phenyl)ureido)phenoxy)-N-MethylpicolinaMide;Sorafenib Impurity 24;Sorafenib Related Compound 16;Sorafenib impurity 7/Methyl 4-(Methylamino)picolinate;Methyl 4-(Methylamino)picolinate;2-Pyridinecarboxylic acid, 4-(methylamino)-, methyl ester;methyl 4-(methylamino)picolinate? (Sorafenib Impurity）;methyl 4-(methylamino)pyridine-2-carboxylate | | CAS: | 1256817-30-7 | | MF: | C8H10N2O2 | | MW: | 166.18 | | EINECS: | | | Product Categories: | | | Mol File: | 1256817-30-7.mol |  |
| | Sorafenib IMpurity Chemical Properties |
| Boiling point | 326.9±27.0 °C(Predicted) | | density | 1.186±0.06 g/cm3(Predicted) | | pka | 4.84±0.10(Predicted) | | CAS DataBase Reference | 1256817-30-7 |
| | Sorafenib IMpurity Usage And Synthesis |
| Uses | Methyl 4-(Methylamino)picolinate is a pyridinyl building block and a useful synthetic intermediate. | | Synthesis | Add 0.8 g (0.004 mol) of 2-chloro-3-trifluoromethyl aniline and 0.7 g (0.004 mol) of N,N-carbonyl diimidazole to 10 mL of dichloromethane, stirring at room temperature for 4 h. Add 0.6 g (0.002 mol) of Compound 2, stirring for 6 h. Distil under reduced pressure and purify by column chromatographic separation (silica gel 200-300 mesh; eluent: V (hexane ):V(ethyl acetate)=5:1), concentrated to dryness to obtain 0.5g product 4-{4-[3-(2-chloro-3-trifluoromethyl-phenyl)-acyl urea]-phenoxy}-pyridine-2-carboxylic acid methyl amine, yield 43.5%, m.p. 188190C, purity 96.7%. (HPLC method: octadecylsilane-bonded silica gel as filler, mobile phase A: phosphate buffer, mobile phase B: V (acetonitrile):V (ethanol) = 70:30, flow rate 0.8 mL/min, detection wavelength 240 nm, RT = 29.61 min). |
| | Sorafenib IMpurity Preparation Products And Raw materials |
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