- D-ALa-Oipr. HCL
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- $0.00/ kg
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2026-04-30
- CAS:39613-92-8
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
- Tenofovir impurity 67
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- $0.00 / 10mg
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2026-03-12
- CAS:39613-92-8
- Min. Order: 10mg
- Purity: 0.98
- Supply Ability: 5g
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| | D-Alanine Isopropyl Ester HCl Basic information |
| Product Name: | D-Alanine Isopropyl Ester HCl | | Synonyms: | D-Alanine Isopropyl Ester HCl;H-D-Ala-OiPro.HCl;H-D-Ala-OiPr·HCl;D-Alanine isopropyl ester (hydrochloride);D-Alanine 1-methylethyl ester HCl;Isopropyl (R)-2-Aminopropanoate Hydrochloride;(R)-isopropyl 2-aminopropanoate hydrochloride;propan-2-yl (2R)-2-aminopropanoate hydrochloride | | CAS: | 39613-92-8 | | MF: | C6H14ClNO2 | | MW: | 167.63 | | EINECS: | | | Product Categories: | | | Mol File: | 39613-92-8.mol |  |
| | D-Alanine Isopropyl Ester HCl Chemical Properties |
| Melting point | 80-82oC | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White |
| | D-Alanine Isopropyl Ester HCl Usage And Synthesis |
| Uses | D-Alanine Isopropyl Ester Hydrochloride is a chiral reagent used in the synthesis of nucleotide prodrugs such as (PSI-7977) for the treatment of hepatitis C. Also used in the preparation of synthetic sweeteners. | | Synthesis | To a three-necked flask equipped with a mechanical stirrer, reflux condenser, thermometer and under nitrogen protection was added L-alanine (5.0 g, 56.1 mmol) and 11.1% w/w solution of isopropanol hydrochloride (73.8 g, 224.5 mmol). The reaction mixture was heated to 80-85 °C for 4 h at reflux. The reaction process was monitored by thin layer chromatography (TLC) using 7:3 ethanol-water as the unfolding agent and ninhydrin for color development. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove isopropanol and the residue was co-evaporated with isopropyl acetate several times to give the final product (R)-isopropyl 2-aminopropionate hydrochloride in oil form (9.4 g, quantitative yield). | | References | [1] Patent: WO2016/151542, 2016, A1. Location in patent: Page/Page column 19
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 20, p. 2622 - 2628
[3] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 12, p. 1197 - 1201
[4] Patent: WO2015/38596, 2015, A1. Location in patent: Page/Page column 237; 238
[5] Patent: WO2016/145142, 2016, A1. Location in patent: Page/Page column 287 |
| | D-Alanine Isopropyl Ester HCl Preparation Products And Raw materials |
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