- AK-1
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- $30.00 / 5mg
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2025-05-08
- CAS:330461-64-8
- Min. Order:
- Purity: 99.01%
- Supply Ability: 10g
- SIRT2 Inhibitor II, AK-1
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- $0.01 / 1KG
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2024-10-22
- CAS:330461-64-8
- Min. Order: 1KG
- Purity: 95%-99%
- Supply Ability: 1kg; 5kg; 10kg
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| | SIRT2 Inhibitor II, AK-1 Basic information |
| Product Name: | SIRT2 Inhibitor II, AK-1 | | Synonyms: | SIRT2 Inhibitor II, AK-1;3-(azepane-1-sulfonyl)-N-(3-nitro-phenyl)-benzamide SIRT2 Inhibitor II, AK-1;AK 1, >=98%;CS-923;AK-1;AK1;AK 1;Benzamide, 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-;AK-1 >=98% (HPLC);inhibit,AK-1,AK 1,AK1,Inhibitor,Sirtuin | | CAS: | 330461-64-8 | | MF: | C19H21N3O5S | | MW: | 403.45 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 330461-64-8.mol |  |
| | SIRT2 Inhibitor II, AK-1 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 0.3 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | SIRT2 Inhibitor II, AK-1 Usage And Synthesis |
| Description | AK-1 is a SIRT2 Inhibitor II that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells. | | Uses | AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM. | | IC 50 | SIRT2: 12.5 μM (IC50) | | References | [1] Ruth Luthi-Carter, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32. DOI:10.1073/pnas.1002924107
[2] Lee SD, et al. AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia. Cancer Lett. 2016 Apr 1;373(1):138-45. DOI:10.1016/j.canlet.2016.01.031
[3] Luthi-Carter R, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32.
[4] David M. Taylor, et al. A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase. ACS Chem Biol. 2011 Jun 17;6(6):540-6. DOI:10.1021/cb100376q
[5] Cheon MG, et al. AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. Cancer Lett. 2015 Jan 28;356(2 Pt B):637-45. DOI:10.1016/j.canlet.2014.10.012 |
| | SIRT2 Inhibitor II, AK-1 Preparation Products And Raw materials |
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