- D-Tyr-Ome.Hcl
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- $0.00 / 1kg
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2025-09-30
- CAS:3728-20-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
- H-D-TYR-OME HCL
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- $0.00 / 25KG
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2025-08-11
- CAS:3728-20-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- H-D-TYR-OME HCL
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- $1.00 / 1KG
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2025-06-24
- CAS:3728-20-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| H-D-TYR-OME HCL Basic information |
| H-D-TYR-OME HCL Chemical Properties |
Melting point | 177-179℃ | storage temp. | Inert atmosphere,2-8°C | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | form | Powder | color | White to off-white | CAS DataBase Reference | 3728-20-9(CAS DataBase Reference) |
| H-D-TYR-OME HCL Usage And Synthesis |
Chemical Properties | Crystalline | Uses | D-Tyrosine methyl ester hydrochloride is an intermediate in the synthesis of oxybutynin chloride (O868525), an inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells. | Synthesis | General procedure for the synthesis of methyl (R)-2-amino-3-(4-hydroxyphenyl)propanoate hydrochloride from methanol and D-tyrosine: (2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid (49) (1.07 g, 5.9 mmol) was dissolved in methanol, and the reaction was completed to give methyl (2R)-2-amino-3-(4-hydroxyphenyl)propanoate (50) . The product characterization data were as follows: melting point 176°C (literature values in agreement); 1H NMR (DMSO-d6) δ: 6.82 (d, J = 8.4 Hz, 2H, ArH3' and ArH5'), 4.13 (t, J = 6.9 Hz, 1H, H2), 3.83 (s, 3H, OCH3), 3.22 (dd, J = 6.0, 14.4 Hz. 1H, 3Ha), 3.12 (dd, J = 6.9, 14.7 Hz, 1H, 3Hb). Mass spectrum (chemical ionization, positive ion mode) m/z: 196 (100%) [M+]. High Resolution Mass Spectrometry (HRMS) calculated value of C10H14NO3: 196.0974, measured value: 196.0985. | References | [1] Organic Letters, 2002, vol. 4, # 2, p. 265 - 267 [2] Organic and Biomolecular Chemistry, 2007, vol. 5, # 4, p. 636 - 643 [3] Patent: WO2006/74501, 2006, A1. Location in patent: Page/Page column 152 [4] Tetrahedron, 2008, vol. 64, # 49, p. 11270 - 11290 [5] Organic and Biomolecular Chemistry, 2005, vol. 3, # 7, p. 1233 - 1239 |
| H-D-TYR-OME HCL Preparation Products And Raw materials |
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