CDKI-83

CDKI-83 Suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	+17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:CDKI-83 CAS:1189558-88-0 Package:50mg;2380USD\|25mg;1820USD\|100mg;3100USD

Company Name:	BOC Sciences
Tel:	1-631-485-4226; 16314854226
Email:	info@bocsci.com
Products Intro:	Product Name:CDKI-83 CAS:1189558-88-0 Remarks:Reach out to us for more information about custom solutions.

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Email:	marketing@targetmol.cn
Products Intro:	Product Name:CDKI-83 CAS:1189558-88-0 Package:50mg/RMB 16800;25mg/RMB 12800;100mg/RMB 21500

CDKI-83 manufacturers

CDKI-83 Basic information

Product Name:	CDKI-83
Synonyms:	CDKI-83;5-Pyrimidinecarbonitrile, 4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-[[4-methyl-3-(4-morpholinylsulfonyl)phenyl]amino]-
CAS:	1189558-88-0
MF:	C21H23N7O3S2
MW:	485.58
EINECS:
Product Categories:
Mol File:	1189558-88-0.mol

CDKI-83 Chemical Properties

Safety Information

MSDS Information

CDKI-83 Usage And Synthesis

Uses	CDKI-83 is a potent CDK9 and CDK1 inhibitor with Ki values of 21 nM and 72 nM for CDK9/T1 and CDK1/B, respectively. CDKI-83 demonstrates effective anti-proliferative activity in human tumour cell lines with a GI50<1 μM. CDKI-83 effectively induces apoptosis in A2780 human ovarian cancer cells. CDKI-83 reduces phosphorylation at Ser-2 of RNA polymerase II (RNAPII) by inhibiting cellular CDK9 activity, and down-regulates Mcl-1 and Bcl-2. CDKI-83 has the potential for anti-cancer research[1].
IC 50	CDK9/T1: 21 nM (Ki); CDK1/B: 72 nM (Ki); CDK2/E: 232 nM (Ki); CDK4/D: 290 nM (Ki); CDK7/H: 405 nM (Ki)
References	[1] Xiangrui Liu, et al. In vitro antitumor mechanism of a novel cyclin-dependent kinase inhibitor CDKI-83. Invest New Drugs. 2012 Jun;30(3):889-97. DOI:10.1007/s10637-011-9641-5

CDKI-83 Preparation Products And Raw materials

Tag:CDKI-83(1189558-88-0) Related Product Information

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.