ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR
| 中文名称 | ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR |
|---|---|
| 中文同义词 | 拉尼西明二盐酸盐;AZD6765 二盐酸盐;化合物 LANICEMINE DIHYDROCHLORIDE;盐酸兰尼司明;153322-06-6;AZD6765 dihydrochloride >=97% (HPLC) |
| 英文名称 | Lanicemine dihydrochloride |
| 英文同义词 | AR-R 15896 dihydrochloride;AZD6765 dihydrochloride;FPL 15896 dihydrochloride;Lanicemine dihydrochloride;ARL-15896;(αS)-α-Phenyl-2-pyridineethanamine dihydrochloride;ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR;Lanicemine hydrochloride |
| CAS号 | 153322-06-6 |
| 分子式 | C13H15ClN2 |
| 分子量 | 234.73 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 153322-06-6.mol |
| 结构式 |  |
ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 在水中的溶解度为20mg/mL，澄清 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 旋光度 (Optical Rotation) | [α]/D +77 to +90°, c =1 in methanol |
| 水溶解性 | H2O: 20mg/mL, clear |
| InChI | 1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1 |
| InChIKey | KHJHFYAGQZYCLC-GXKRWWSZSA-N |
| SMILES | [Cl-].[Cl-].[N+H3][C@@H](Cc2[n+H]cccc2)c1ccccc1 |
Lanicemine (AZD6765) dihydrochloride 是一种低捕获的 NMDA 受体拮抗剂，Ki 为 0.56-2.1 μM。CHO 和爪蟾卵母细胞中，IC50 分别为 4-7 μM 和 6.4 μM。具有抗抑郁作用。
NMDA receptor
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 3, 10 or 30 mg/kg |
| Administration: | Intraperitoneal |
| Result: | Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-108235A | ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR Lanicemine dihydrochloride | 153322-06-6 | 5mg | 600元 |
| 2026/06/05 | HY-108235A | ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR Lanicemine dihydrochloride | 153322-06-6 | 10mM * 1mLin DMSO | 660元 |