|
|
| Product Name: | SAPK1A | | Synonyms: | Anti-MAPK9 antibody produced in goat;ANTI-MOUSE MAPK9 (CENTER) antibody produced in rabbit;ANTI-MAPK9 antibody produced in mouse;ANTI-JNK2 (MAPK9)(C-TERMINAL) antibody produced in rabbit;p54a;JNK2;JNK2ALPHA2;JNK2ALPHA2/SAPK1A | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![SAPK1A Structure]() |
| | SAPK1A Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | mouse | | Specific Activity | 11-15nmol/min·mg |
| Storage Class | 10 - Combustible liquids |
| | SAPK1A Usage And Synthesis |
| Uses | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene′s mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq) | | Biological Activity | JNK2 is a member of the JNK family th at acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK2 targets specific transcription factors, and mediates immediate-early gene expression in response to various cell stimuli. Both UV radiation and the proinflammatory cytokine TNFα can induce JNK2. JNK2 play a main role in the regulation of regional specific apoptosis during early brain development and providing protection against autoimmune diabetes. |
| | SAPK1A Preparation Products And Raw materials |
|