| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:(±)8(9)-EET
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-6206333 13167063860 |
| Email: |
anhua.mao@aladdin-e.com |
| Products Intro: |
Product Name:(±)8,9-Epoxyeicosa-5Z,11Z,14Z-trienoic acid
CAS:81246-85-7
Purity:≥98%, 100ug/mL in ethanol Package:50μg/RMB 1338.90;100μg/RMB 2471.90;500μg/RMB 9475.90
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| Company Name: |
Yichang Zhongyitai Trading Co., Ltd.
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| Tel: |
0717-6449896 13886658719 |
| Email: |
root@zhongyitai.com |
| Products Intro: |
Product Name:8,9-Epoxy-5(Z),11(Z),14(Z)-Eicosatrienoic acid
CAS:81246-85-7
Purity:98+% Package:100ug
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| | (+/-)8,9-EET Basic information |
| Product Name: | (+/-)8,9-EET | | Synonyms: | (+/-)8(9)-EPETRE;8(9)-EPETRE;(+/-)8(9)-EPOXY-5Z,11Z,14Z-EICOSATRIENOIC ACID;(+/-)8,9-EPOXYEICOSA-5Z,11Z,14Z-TRIENOIC ACID;(+/-)8,9-EET;8,9-EET;8,9-epoxyeicosatrienoicacid;(Z)-7-[3-[(2Z,5Z)-undeca-2,5-dienyl]oxiran-2-yl]hept-5-enoic acid | | CAS: | 81246-85-7 | | MF: | C20H32O3 | | MW: | 320.47 | | EINECS: | | | Product Categories: | | | Mol File: | 81246-85-7.mol |  |
| | (+/-)8,9-EET Chemical Properties |
| Boiling point | 456.2±20.0 °C(Predicted) | | density | 0.983±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMF: 50 mg/ml
DMSO: 50 mg/ml
Ethanol: 50 mg/mlPBS pH 7.2: 1 mg/ml | | pka | 4.77±0.10(Predicted) |
| | (+/-)8,9-EET Usage And Synthesis |
| Uses | (+/-)8,9-Epoxyeicosa-5Z,11Z,14Z-trienoic acid is a glucagon inducer in pancreatic islets. | | References | [1] N. CHACOS . Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid[J]. Biochemical and biophysical research communications, 1982, 104 3: Pages 916-922. DOI: 10.1016/0006-291x(82)91336-5
[2] E. OLIW J O F Guengerich. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates.[J]. The Journal of Biological Chemistry, 1982, 109 1: 3771-3781. DOI: 10.1016/s0021-9258(18)34848-8
[3] JI Y. ZHANG . Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase[J]. Biochemical and biophysical research communications, 1992, 183 1: Pages 138-143. DOI: 10.1016/0006-291x(92)91619-2
[4] JONAS BYSTROM. Endogenous epoxygenases are modulators of monocyte/macrophage activity.[J]. PLoS ONE, 2011: e26591. DOI: 10.1371/journal.pone.0026591
[5] AMY A RAND. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 17: 4370-4375. DOI: 10.1073/pnas.1616893114
[6] T KATOH. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney.[J]. American Journal of Physiology, 1991, 261 4 Pt 2: F578-86. DOI: 10.1152/ajprenal.1991.261.4.f578
[7] FADUMO A. ISSE . Quantification of Epoxyeicosatrienoic acids Enantiomers: The development of reliable and practical liquid chromatography mass Spectrometry assay[J]. Journal of Chromatography B, 2024, 1247: Article 124346. DOI: 10.1016/j.jchromb.2024.124346
[8] ZONGYUAN WU, FANG WEI* Analytical Strategy for Oxylipin Annotation by Combining Chemical Derivatization-Based Retention Index Algorithm and Feature Tandem Mass Spectrometric Fragmentation as a Biomarker Discovery Tool[J]. Analytical Chemistry, 2023, 95 43: 15933-15942. DOI: 10.1021/acs.analchem.3c02789
[9] ANDREI KORNILOV. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13-hydroxyeicosadienoic acid.[J]. The Journal of Biological Chemistry, 2019, 294 23: 9225-9238. DOI: 10.1074/jbc.ra119.008915
[10] REUT LEVI-ROSENZVIG . 5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation[J]. Free Radical Biology and Medicine, 2017, 103: Pages 87-94. DOI: 10.1016/j.freeradbiomed.2016.12.022 |
| | (+/-)8,9-EET Preparation Products And Raw materials |
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