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| | 2-Amino-3-chloropyrazine Basic information |
| | 2-Amino-3-chloropyrazine Chemical Properties |
| Melting point | 167-171°C | | Boiling point | 248.1±35.0 °C(Predicted) | | density | 1.437±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 2.37±0.10(Predicted) | | form | powder to crystal | | color | White to Light yellow to Dark green | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C4H4ClN3/c5-3-4(6)8-2-1-7-3/h1-2H,(H2,6,8) | | InChIKey | AEVSSZHXGJAPIE-UHFFFAOYSA-N | | SMILES | C1(N)=NC=CN=C1Cl | | CAS DataBase Reference | 6863-73-6 |
| Risk Statements | 36/37/38 | | Safety Statements | 26-37 | | HazardClass | IRRITANT | | HS Code | 29339900 |
| | 2-Amino-3-chloropyrazine Usage And Synthesis |
| Uses | It is employed in the synthesis and tuberculostatic activity of N-pyrazinylthiourea. | | Synthesis | General procedure for the synthesis of 2-amino-3-chloropyrazine from 2,3-dichloropyrazine: 2,3-dichloropyrazine (3.5 g, 0.023 mol) was suspended in a mixture of 25% ammonia (20 mL) and tetrahydrofuran (THF, 20 mL) in an autoclave reactor and heated to react for 18 h at 100 °C. The reaction was completed by cooling to room temperature. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated under reduced pressure to a minimum volume. The residue was ground with distilled water (15 mL) and after filtration, the solid product was dried to give 2-amino-3-chloropyrazine as a light yellow crystalline solid (2.75 g, 90% yield). Mass spectrum (electrospray positive ionization mode, ES+) m/z: 130.1. 1H NMR (400 MHz, CDCl3): δ 7.94 (d, J=2.53 Hz, 1H), 7.72 (d, J=2.53 Hz, 1H), 4.90-5.12 (broad single peak, 2H). | | References | [1] Patent: US2012/59162, 2012, A1. Location in patent: Page/Page column 38-39
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4196 - 4212
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3454 - 3459
[4] Patent: US2014/364414, 2014, A1. Location in patent: Paragraph 0438-0440
[5] Patent: WO2010/69684, 2010, A1. Location in patent: Page/Page column 96 |
| | 2-Amino-3-chloropyrazine Preparation Products And Raw materials |
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